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Research ArticleImaging

Automated Quantitative Analysis of American College of Radiology PET Phantom Images

Frank P. DiFilippo, Meghal Patel and Sagar Patel
Journal of Nuclear Medicine Technology September 2019, 47 (3) 249-254; DOI: https://doi.org/10.2967/jnmt.118.221317
Frank P. DiFilippo
Department of Nuclear Medicine, Cleveland Clinic, Cleveland, Ohio
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Meghal Patel
Department of Nuclear Medicine, Cleveland Clinic, Cleveland, Ohio
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Sagar Patel
Department of Nuclear Medicine, Cleveland Clinic, Cleveland, Ohio
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  • FIGURE 1.
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    FIGURE 1.

    Example of standard quantitative measurements specified for ACR PET phantom evaluation. Transaxial slice of 10-mm thickness is generated that includes hot and cold vials. Circular ROIs of 25-mm diameter are drawn, centered over each vial. Circular ROI (diameter between 60 and 70 mm) is drawn over background region. Some pass/fail criteria are based on SUV measurements of these regions, whereas other pass/fail criteria depend on qualitative assessment of hot vial visibility, cold rod visibility, and background uniformity. SUVbw = SUV normalized to body weight. Color version of this figure is available as supplemental file at http://tech.snmjournals.org.

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    FIGURE 2.

    Histograms of SUV and normalized SUV measurements of 16-mm hot vial for 17 phantom studies. From left to right: SUVmax using ACR ROI, SUVvial using cylindric VOI, normalized SUVmax using ACR ROI, and normalized SUVvial using cylindric VOI. Most consistent results are obtained with normalized SUVvial measurements.

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    FIGURE 3.

    Histograms of SUVmax ratio (left) and SUVvial ratio (right) for 16- to 25-mm hot vials. SUVvial ratios were more consistent and, unlike SUVmax ratios, did not have outliers greater than 1.0.

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    FIGURE 4.

    Cold rod contrast versus rod diameter (mean values for 17 phantom studies analyzed). SD for each point is approximately 0.01; error bars are smaller than size of markers.

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    TABLE 1

    Hot Vial SUVmax and SUVvial Measured With and Without Normalization Using ACR ROIs and Cylindric VOIs

    Hot vial diameter (mm)SUVmaxSUVvialSUVmax, NormalizedSUVvial, Normalized
    252.56 ± 6.7%2.37 ± 6.2%2.54 ± 3.6%2.46 ± 3.1%
    162.43 ± 9.7%2.16 ± 7.2%2.41 ± 7.0%2.24 ± 3.8%
    122.02 ± 6.0%1.82 ± 5.6%2.01 ± 5.2%1.89 ± 2.4%
    81.35 ± 9.4%1.29 ± 8.3%1.34 ± 6.3%1.34 ± 3.7%
    • SUVmax using 25-mm circular ROI in 10-mm slice. SUVvial using cylindric VOI. Normalized SUVs account for actual syringe activities and dilution vessel used during phantom preparation.

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    TABLE 2

    Hot Vial SUV Ratios Measured Using ACR ROIs and Cylindric VOIs

    Hot vial ratioSUVmax ratioSUVvial ratio
    16 mm/25 mm0.95 ± 5.0%0.91 ± 2.7%
    12 mm/25 mm0.79 ± 6.7%0.77 ± 3.3%
    8 mm/25 mm0.53 ± 5.2%0.54 ± 3.7%
    • SUVmax using 25-mm circular ROI in 10-mm slice. SUVvial using cylindric VOI.

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    TABLE 3

    Cold Rod Contrast for 6 Sectors of ACR PET Phantom

    ParameterRod diameter (mm)
    12.711.19.57.96.44.8
    Mean contrast0.5980.5080.3890.2340.080−0.011
    SD0.0110.0070.0080.0120.0050.007
    • Data are for 17 studies.

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Journal of Nuclear Medicine Technology: 47 (3)
Journal of Nuclear Medicine Technology
Vol. 47, Issue 3
September 1, 2019
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Automated Quantitative Analysis of American College of Radiology PET Phantom Images
Frank P. DiFilippo, Meghal Patel, Sagar Patel
Journal of Nuclear Medicine Technology Sep 2019, 47 (3) 249-254; DOI: 10.2967/jnmt.118.221317

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Automated Quantitative Analysis of American College of Radiology PET Phantom Images
Frank P. DiFilippo, Meghal Patel, Sagar Patel
Journal of Nuclear Medicine Technology Sep 2019, 47 (3) 249-254; DOI: 10.2967/jnmt.118.221317
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Keywords

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