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Research ArticleImaging

Enhanced Gastric Emptying Scintigraphy to Assess Fundic Accommodation Using Intragastric Meal Distribution and Antral Contractility

Perry Orthey, Simin Dadparvar, Henry P. Parkman and Alan H. Maurer
Journal of Nuclear Medicine Technology June 2019, 47 (2) 138-143; DOI: https://doi.org/10.2967/jnmt.118.215566
Perry Orthey
Section of Gastroenterology, Department of Medicine, and Section of Nuclear Medicine, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania
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Simin Dadparvar
Section of Gastroenterology, Department of Medicine, and Section of Nuclear Medicine, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania
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Henry P. Parkman
Section of Gastroenterology, Department of Medicine, and Section of Nuclear Medicine, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania
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Alan H. Maurer
Section of Gastroenterology, Department of Medicine, and Section of Nuclear Medicine, Department of Radiology, Temple University School of Medicine, Philadelphia, Pennsylvania
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  • FIGURE 1.
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    FIGURE 1.

    Anatomic division of stomach into proximal and distal halves by semiautomated software. (A) Demonstration of how software automatically contours outer border for total-stomach ROI (solid line) from summed set of all static anterior images. (B) Application of total-stomach ROI to each static image. In this case, image is anterior image acquired immediately after meal ingestion. By finding midpoint between opposing points of total-stomach ROI, longitudinal axis through stomach is generated (dotted line). Line perpendicular to longitudinal axis is then defined at point dividing longitudinal axis into equal halves to separate upper and lower segments of stomach.

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    FIGURE 2.

    Fourier frequency and amplitude analysis used to segment antrum (distal stomach) from proximal stomach based on antral contractions. (A) Fast Fourier transformation of all pixels in DACS image set: amplitude and frequency response. (B) Red border on amplitude response indicating threshold of high-amplitude pixels. Same border is applied to frequency response. (C) Region of dominant frequency. Green border indicates contiguous region of pixels that have same frequency (gray color). (D) Starting location of antral contractions. Antrum-defined ROI (green border) using region of dominant frequency from C and red border from B is applied to one image of gastric emptying study. Purple dotted line is longitudinal axis as shown in Figure 1B. Yellow X is intersection of longitudinal axis, and convex boundary around green border is starting location of antral contractions.

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    FIGURE 3.

    Time to onset of antral contractions. (A) Vertical rectangular ROI is placed over midportion of gastric antrum from one frame of serial anterior dynamic images used to generate time–activity curves shown in B. (B) y-axis is counts generated in antral ROI shown in A over time. x-axis is frame number, with 400 frames at 3 s per image. Time to onset of regular antral contractions is seen at image 278 or at 13.9 min (arrow) after immediately-after-meal static images.

  • FIGURE 4.
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    FIGURE 4.

    (A) Total and regional gastric retention over time using anatomic division of stomach into halves. (B) Total and regional gastric retention over time using Fourier frequency and amplitude to separate antrum from remaining proximal stomach.

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    TABLE 1

    Results Summary (n = 20 Healthy Subjects)

    Parameter0 min30 min60 min120 min180 min240 min
    IMD: gastric division into proximal  and distal halves0.76 ± 0.140.50 ± 0.120.37 ± 0.130.13 ± 0.080.03 ± 0.040.01 ± 0.01
    IMD: gastric division into proximal  and distal segments with Fourier-defined  antral region0.85 ± 0.140.61 ± 0.160.48 ± 0.170.20 ± 0.100.06 ± 0.040.02 ± 0.02
    Total gastric retention (%)100.0 ± 0.086.2 ± 6.972.1 ± 11.539.8 ± 12.816.4 ± 9.95.8 ± 6.0
    Antral frequency (cycles/min)3.09 ± 0.313.30 ± 0.733.15 ± 0.282.96 ± 0.35NANA
    Antral ejection fraction (%)26.28 ± 13.7429.43 ± 13.4227.96 ± 15.3126.95 ± 9.38NANA
    Contraction speed (mm/s)2.91 ± 1.893.04 ± 1.653.54 ± 0.902.67 ± 1.37NANA
    • IMD = ratio of count in proximal stomach to total gastric count immediately after meal ingestion; NA = not available because of low count caused by majority of meal’s having left stomach.

    • Data are mean ± SD.

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Journal of Nuclear Medicine Technology: 47 (2)
Journal of Nuclear Medicine Technology
Vol. 47, Issue 2
June 1, 2019
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Enhanced Gastric Emptying Scintigraphy to Assess Fundic Accommodation Using Intragastric Meal Distribution and Antral Contractility
Perry Orthey, Simin Dadparvar, Henry P. Parkman, Alan H. Maurer
Journal of Nuclear Medicine Technology Jun 2019, 47 (2) 138-143; DOI: 10.2967/jnmt.118.215566

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Enhanced Gastric Emptying Scintigraphy to Assess Fundic Accommodation Using Intragastric Meal Distribution and Antral Contractility
Perry Orthey, Simin Dadparvar, Henry P. Parkman, Alan H. Maurer
Journal of Nuclear Medicine Technology Jun 2019, 47 (2) 138-143; DOI: 10.2967/jnmt.118.215566
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Keywords

  • gastric emptying
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