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Research ArticleImaging

Guidelines for Quality Control Testing of Molecular Breast Imaging Systems

Sara M. Nardinger, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Courtney M. Solberg, Michael K. O’Connor and Carrie B. Hruska
Journal of Nuclear Medicine Technology December 2018, 46 (4) 349-354; DOI: https://doi.org/10.2967/jnmt.118.209221
Sara M. Nardinger
Department of Radiology, Mayo Clinic, Rochester, Minnesota
CNMT
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Thuy D. Tran
Department of Radiology, Mayo Clinic, Rochester, Minnesota
CNMT
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Tiffinee N. Swanson
Department of Radiology, Mayo Clinic, Rochester, Minnesota
CNMT
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Lacey R. Ellingson
Department of Radiology, Mayo Clinic, Rochester, Minnesota
CNMT
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Courtney M. Solberg
Department of Radiology, Mayo Clinic, Rochester, Minnesota
CNMT
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Michael K. O’Connor
Department of Radiology, Mayo Clinic, Rochester, Minnesota
PhD
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Carrie B. Hruska
Department of Radiology, Mayo Clinic, Rochester, Minnesota
PhD
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  • FIGURE 1.
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    FIGURE 1.

    Examples of 99mTc-pertechnetate and 99mTc-sestamibi in plastic flask. (A) 99mTc-pertechnetate mixture is homogeneous within flask. (B) Distribution of 99mTc-sestamibi mixture is nonuniform, and there are increased counts along surface of flask.

  • FIGURE 2.
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    FIGURE 2.

    Proper positioning for uniformity flood acquisition using refillable 99mTc source. Source is positioned between upper and lower detectors of dual-head cadmium-zinc-telluride system. Gantry is angled to ensure that any air bubbles in phantom are outside field of view.

  • FIGURE 3.
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    FIGURE 3.

    Potential of new 57Co sheet sources to create artifacts. (A) Uniformity flood acquisition obtained using 57Co sheet source and 57Co correction map. (B) Uniformity flood acquisition obtained using 99mTc flood source and 57Co correction map immediately after acquisition of image in A. Artifact (arrow) can be seen over one module in middle of detector.

  • FIGURE 4.
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    FIGURE 4.

    Examples of aliasing artifacts on pixelated imaging system. (A) Aliasing artifact from imaging bar phantom. (B) Zoomed image of artifact from line source for evaluating spatial resolution.

  • FIGURE 5.
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    FIGURE 5.

    Recommended setup for measurement of system sensitivity. (A) For single-head system, flask is filled with just enough water to cover surface area of flask when lying on its side. (B) For dual-head system, flask is filled completely with water to minimize differences between detector geometry. Both images can be acquired simultaneously.

  • FIGURE 6.
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    FIGURE 6.

    Contrast-detail phantom. (A) Phantom contains 3-cm-thick central section with multiple hole sizes and depths. (B) Display of image setup using two 1.5-cm-thick acrylic plates on either side of contrast-detail phantom. Camera is angled to move air bubbles out of field of view.

  • FIGURE 7.
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    FIGURE 7.

    Sample contrast-detail phantom images. These images were acquired at distances of 1.5 cm (A), 3.0 cm (B), and 4.5 cm (C) from collimator face.

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    TABLE 1

    Recommended Quality Control Testing Program for MBI Systems

    TestEquipmentFrequencyAcquisition detailsPassing criterion
    Uniformity57Co sheet source  or fillable phantomDaily7.5 million counts≤5% integral uniformity
    Spatial resolution4-quadrant bar phantomSemiannually7.5 million counts; phantom  angled across field of viewMeets manufacturer’s  specifications
    SensitivityFlaskAnnually120-s images≤10% difference between  2 detectors
    Energy resolutionPoint sourceAnnually2-keV energy windows; 1-min  imagesFull width at half maximum  ≤ 10%
    Lesion contrastContrast-detail phantomQuarterly1 million counts; images at  3 depthsCNR > 3; count number of  visible lesions at each depth
    • * All tests should be performed at acceptance testing and after major service work.

    • CNR = contrast-to-noise ratio.

    • View popup
    TABLE 2

    Suggested Number of Lesions Visualized in Contrast-Detail Phantom for Satisfactory, Marginal, and Fail Criteria

    DistanceSatisfactoryMarginalFail
    1.5 cm4240<40
    3.0 cm3735<35
    4.5 cm3230<30
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Journal of Nuclear Medicine Technology: 46 (4)
Journal of Nuclear Medicine Technology
Vol. 46, Issue 4
December 1, 2018
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Guidelines for Quality Control Testing of Molecular Breast Imaging Systems
Sara M. Nardinger, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Courtney M. Solberg, Michael K. O’Connor, Carrie B. Hruska
Journal of Nuclear Medicine Technology Dec 2018, 46 (4) 349-354; DOI: 10.2967/jnmt.118.209221

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Guidelines for Quality Control Testing of Molecular Breast Imaging Systems
Sara M. Nardinger, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Courtney M. Solberg, Michael K. O’Connor, Carrie B. Hruska
Journal of Nuclear Medicine Technology Dec 2018, 46 (4) 349-354; DOI: 10.2967/jnmt.118.209221
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