Article Figures & Data
Figures
- FIGURE 1.
Chromatography diagrams of alternative (A) and standard (B) methods for radiochemical purity testing of radiopharmaceuticals.
- FIGURE 2.
Radiochemical purity of 99mTc-HMPAO (left), 99mTc-HMDP (middle), and 99mTc-tetrofosmin (right), obtained by standard and miniaturized strips in commercial reconstituted samples. Correlation coefficients were, respectively, 0.97, 0.93, and 0.86 (with P = 0.0013, P < 0.0001, and P < 0.0001, respectively).
- FIGURE 3.
ITLC-SA with acetone:dichloromethane (85:65) of batch of 99mTc-tetrofosmin: (A) Manufacturer's method: radiochemical purity, 94.4%. (B) Miniaturized method: radiochemical purity, 93.7%. Impurities are HRTc (peak 1), unknown impurities (peaks 2 and 3), 99mTc-tetrofosmin (peak 4), and 99mTcO4− (peak 5), accounting for 2% of total radioactivity.
Tables
- TABLE 1
Rf Ranges for Peaks of Most Common 99mTc Components in Radiopharmaceutical Preparations
Agent Component Standard strips Miniaturized strips 99mTc-HMPAO NaCl MEK NaCl MEK 99mTc-pertechnetate 0.8–1 0.8–1 0.8–1 0.8–1 99mTc-albumin 0–0.4 0–0.2 0–0.2 0–0.2 99mTc-HMPAO hydrophilic 0–0.4 0–0.2 0–0.2 0–0.2 99mTc-HMPAO lipophilic 0–0.4 0.8–1 0–0.2 0.8–1 99mTc-HMDP NaCl MeOH/H2O* NaCl MeOH/H2O 99mTc-pertechnetate 0–0.15 0.4–1 0–0.15 0.5–1 99mTc-albumin colloid 0–0.15 0–0.4 0–0.15 0–0.5 99mTc-HMDP 0.4–1 0–0.4 0.4–1 0.5–1 99mTc-tetrofosmin AcO/DCM† AcO/DCM 99mTc-pertechnetate 0.8–1 0.9–1 99mTc-albumin colloid 0–0.25 0–0.3 99mTc-tetrofosmin 0.25–0.8 0.3–0.9
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