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Research ArticleImaging

Effect of Outflow Tract Contributions to 82Rb-PET Global Myocardial Blood Flow Computations

Andrew Van Tosh, Nathaniel Reichek, Christopher J. Palestro and Kenneth J. Nichols
Journal of Nuclear Medicine Technology June 2016, 44 (2) 78-84; DOI: https://doi.org/10.2967/jnmt.116.173005
Andrew Van Tosh
1Research Department, St. Francis Hospital, Roslyn, New York; and
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Nathaniel Reichek
1Research Department, St. Francis Hospital, Roslyn, New York; and
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Christopher J. Palestro
2Division of Nuclear Medicine and Molecular Imaging, Northwell Health, Manhasset and New Hyde Park, New York
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Kenneth J. Nichols
2Division of Nuclear Medicine and Molecular Imaging, Northwell Health, Manhasset and New Hyde Park, New York
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  • FIGURE 1.
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    FIGURE 1.

    American Heart Association/American College of Cardiology 17-segment map.

  • FIGURE 2.
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    FIGURE 2.

    Segmentation and chamber identification. LV myocardial segments are identified (top row), as well as right ventricular (RV) and LV blood pools (bottom row).

  • FIGURE 3.
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    FIGURE 3.

    Polar map display of MFRs. Values of segments 2 and 3 are markedly reduced compared with values of all other segments.

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    FIGURE 4.

    Stress (top) and rest (bottom) horizontal long-axis sections from septum (left) to lateral wall (right) for patient with essentially normal perfusion, all summed perfusion scores equal to 0, and normal function (ejection fraction, 70%). Respective flow inhomogeneities (ratio of SD to mean) were 15%, 23%, and 15% for rest MBF, stress MBF, and MFR when only segments 4–17 were included but increased to 31%, 34%, and 22% when all 17 segments were included.

  • FIGURE 5.
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    FIGURE 5.

    82Rb polar perfusion maps for stress (left) and rest (right) for the patient of Figure 4 display markedly reduced perfusion in basal–septal territories.

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    FIGURE 6.

    Bland–Altman plot of differences vs. mean values for 17-segment stress MBF (MBFstress17) and 14-segment stress MBF (MBFstress14), in units of mL/g/min.

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    TABLE 1

    Comparison of MBF Parameters Obtained by Including All 17 LV Segments vs. Only Segments 4–17

    ParameterSegments 1–17Segments 4–17
    Rest MBF (mL/g/min)0.78 ± 0.50*0.85 ± 0.54
    Stress MBF (mL/g/min)1.50 ± 0.88*1.67 ± 0.96
    MFR2.11 ± 1.00*2.16 ± 1.00
    Rest CVR (mm Hg/mL/g/min)159 ± 86*147 ± 81
    Stress CVR (mm Hg/mL/g/min)85 ± 52*76 ± 48
    %SD of rest MBF39% ± 10%*31% ± 10%
    %SD of stress MBF42% ± 12%*32% ± 11%
    %SD of MFR28% ± 18%*25% ± 10%
    • ↵* Paired t test P < 0.0001 vs. segments 4–17.

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    TABLE 2

    Differences and Percentage Differences Between 14- and 17-Segment Mean Values

    ParameterMean differenceMaximum differenceMean % differenceMaximum % difference
    Rest MBF (mL/g/min)0.06 ± 0.050.248.2% ± 4.2%16.8%
    Stress MBF (mL/g/min)0.14 ± 0.100.549.3% ± 4.5%16.3%
    MFR0.02 ± 0.070.261.1% ± 3.1%15.0%
    Rest CVR (mm Hg/mL/g/min)−12.7 ± 8.7−43.9−8.5% ± 4.2%−17.5%
    Stress CVR (mm Hg/mL/g/min)−8.2 ± 5.9−27.8−10.5% ± 5.2%−18.8%
    %SD of rest MBF−7.6% ± 5.1%−22.0%——
    %SD of stress MBF−9.4% ± 5.4%−20.0%——
    %SD of MFR−2.6% ± 14.1%12.0%——
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    TABLE 3

    Comparison of MBF Parameters for Patients Divided into Groups for Whom 14-Segment MFR Was Below or Above Median

    MFR < 1.95MFR ≥ 1.95
    ParameterSegments 1–17Segments 4–17Segments 1–17Segments 4–17
    Rest MBF (mL/g/min)0.91 ± 0.58*0.98 ± 0.610.67 ± 0.40*0.72 ± 0.42
    Stress MBF (mL/g/min)1.23 ± 0.78*1.35 ± 0.841.81 ± 0.92*1.98 ± 0.97
    MFR1.40 ± 0.34*1.42 ± 0.352.86 ± 0.94*2.90 ± 0.91
    Rest CVR (mm Hg/mL/g/min)136 ± 79*125 ± 73182 ± 89*167 ± 83
    Stress CVR (mm Hg/mL/g/min)103 ± 60*94 ± 5664 ± 31*58 ± 28
    %SD of rest MBF39% ± 10%*31% ± 10%38% ± 9%*30% ± 9%
    %SD of stress MBF43% ± 12%*34% ± 13%38% ± 9%*30% ± 9%
    %SD of MFR26% ± 11%30% ± 23%24% ± 9%26% ± 9%
    • ↵* P < 0.0001 vs. segments 4–17.

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Journal of Nuclear Medicine Technology: 44 (2)
Journal of Nuclear Medicine Technology
Vol. 44, Issue 2
June 1, 2016
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Effect of Outflow Tract Contributions to 82Rb-PET Global Myocardial Blood Flow Computations
Andrew Van Tosh, Nathaniel Reichek, Christopher J. Palestro, Kenneth J. Nichols
Journal of Nuclear Medicine Technology Jun 2016, 44 (2) 78-84; DOI: 10.2967/jnmt.116.173005

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Effect of Outflow Tract Contributions to 82Rb-PET Global Myocardial Blood Flow Computations
Andrew Van Tosh, Nathaniel Reichek, Christopher J. Palestro, Kenneth J. Nichols
Journal of Nuclear Medicine Technology Jun 2016, 44 (2) 78-84; DOI: 10.2967/jnmt.116.173005
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Keywords

  • PET/CT
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