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Research ArticleImaging

Influence of Statistical Fluctuation on Reproducibility and Accuracy of SUVmax and SUVpeak: A Phantom Study

Go Akamatsu, Yasuhiko Ikari, Hiroyuki Nishida, Tomoyuki Nishio, Akihito Ohnishi, Akira Maebatake, Masayuki Sasaki and Michio Senda
Journal of Nuclear Medicine Technology September 2015, 43 (3) 222-226; DOI: https://doi.org/10.2967/jnmt.115.161745
Go Akamatsu
1Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan; and
2Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Yasuhiko Ikari
1Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan; and
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Hiroyuki Nishida
1Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan; and
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Tomoyuki Nishio
1Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan; and
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Akihito Ohnishi
1Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan; and
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Akira Maebatake
2Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Masayuki Sasaki
2Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Michio Senda
1Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan; and
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  • FIGURE 1.
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    FIGURE 1.

    Method of extracting PET acquisition data of various scan times from long list-mode data. Fifteen PET images for each scan time were generated, totaling 76 PET images.

  • FIGURE 2.
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    FIGURE 2.

    All PET images obtained in this study are shown. Images are not identical even with the same scanning time. Visualization of hot spheres depend on scanning time.

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    FIGURE 3.

    (A) PET images having highest (#12) and lowest (#2) SUVmax,10 among the 15 frames of the 60-s scan. SUVmax,10 fluctuates considerably. (B) Three-dimensional graphics of 37-mm-diameter hot sphere with 1,800- and 60-s scan times. Maximum pixel value of small hot sphere in low-count-statistics image was often higher than that in high-count-statistics image.

  • FIGURE 4.
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    FIGURE 4.

    SUVmax and SUVpeak in relation to sphere sizes and scan times. SUVmax,37 for 60-s image had positive biases of 28.3%, compared with SUVref,max,37. SUVmax was overestimated as sphere size increased and scanning time decreased. SUVpeak was almost constant irrespective of scan time.

Tables

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    TABLE 1

    Variability (CV) of SUVmax and SUVpeak of Hot Spheres and Background in Relation to Scanning Time

    Scan time (s)
    Index6090120150180
    CVmax,1011.010.911.68.88.5
    CVmax,137.06.76.06.25.3
    CVmax,178.87.97.05.64.8
    CVmax,226.37.16.25.94.5
    CVmax,285.74.53.93.02.7
    CVmax,373.12.02.71.82.1
    CVpeak,133.53.63.53.42.7
    CVpeak,173.33.83.42.82.1
    CVpeak,224.63.02.72.72.9
    CVpeak,283.13.12.82.12.2
    CVpeak,372.32.42.12.21.5
    CVbackground16.513.611.810.79.8
    N10 mm10.18.57.66.96.1
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    TABLE 2

    Accuracy of SUVmax and SUVpeak in Relation to Scanning Time

    Scan time (sec)
    Index6090120150180
    %Diffmax,1012.98.58.47.07.2
    %Diffmax,139.49.16.96.46.0
    %Diffmax,1711.09.17.57.05.7
    %Diffmax,2214.412.88.98.46.6
    %Diffmax,2822.715.913.711.410.2
    %Diffmax,3728.319.116.613.712.3
    %Diffpeak,133.73.53.12.82.3
    %Diffpeak,172.82.72.72.41.8
    %Diffpeak,223.42.32.32.32.4
    %Diffpeak,283.22.72.21.71.8
    %Diffpeak,374.44.33.02.92.3
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Journal of Nuclear Medicine Technology: 43 (3)
Journal of Nuclear Medicine Technology
Vol. 43, Issue 3
September 1, 2015
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Influence of Statistical Fluctuation on Reproducibility and Accuracy of SUVmax and SUVpeak: A Phantom Study
Go Akamatsu, Yasuhiko Ikari, Hiroyuki Nishida, Tomoyuki Nishio, Akihito Ohnishi, Akira Maebatake, Masayuki Sasaki, Michio Senda
Journal of Nuclear Medicine Technology Sep 2015, 43 (3) 222-226; DOI: 10.2967/jnmt.115.161745

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Influence of Statistical Fluctuation on Reproducibility and Accuracy of SUVmax and SUVpeak: A Phantom Study
Go Akamatsu, Yasuhiko Ikari, Hiroyuki Nishida, Tomoyuki Nishio, Akihito Ohnishi, Akira Maebatake, Masayuki Sasaki, Michio Senda
Journal of Nuclear Medicine Technology Sep 2015, 43 (3) 222-226; DOI: 10.2967/jnmt.115.161745
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Keywords

  • SUVmax
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  • statistical fluctuation
  • reproducibility
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