Article Figures & Data
Figures
- FIGURE 1.
Effect of drug treatment on 131I uptake by thyroid. Shown are effects of treatment with H1 receptor antagonist (promethazine), H2 receptor antagonist (famotidine), and PPI (esomeprazole) on uptake of 131I (NaI) by entire thyroid (resected en bloc) in rat at 1 d (white bars) and 8 d (black bars) after intraperitoneal administration of radioiodine. Rat cohorts received either no additional drug (controls) or subcutaneous injections of specific drug (famotidine, promethazine, or esomeprazole) commencing 1 d before 131I (NaI) administration and continuing daily thereafter until day of euthanasia (1 or 8 d after radioiodine administration). White and black bars denote mean uptake value (%ID per entire thyroid) of radioiodine per cohort (n = 8 for each cohort). Error bars represent SEM. Compared with untreated control rats, statistically significant increases in radioiodine uptake by thyroid occurred at both 1 and 8 d after 131I administration only in promethazine-treated rats. Treatment with esomeprazole and famotidine did not alter radioiodine uptake by salivary tissue. *Statistically significant differences between drug-treated and control rats.
- FIGURE 2.
Effect of drug treatment on 131I uptake by salivary tissue. Shown are effects of H1 receptor antagonist (promethazine), H2 receptor antagonist (famotidine), and PPI (esomeprazole) on uptake of 131I (NaI) by salivary gland tissue in rat at 1 d (white bars) and 8 d (black bars) after intraperitoneal administration of radioiodine. Rat cohorts received either no additional drug (controls) or subcutaneous injections of specific drug (famotidine, promethazine, or esomeprazole) commencing 1 d before 131I (NaI) administration and continuing daily thereafter until day of euthanasia (1 or 8 d after radioiodine administration). White and black bars denote mean uptake value (%ID/g) of radioiodine per cohort (n = 8 for each cohort). Error bars represent SEM. Compared with untreated control rats, statistically significant increases in radioiodine uptake by salivary gland tissue occurred at both 1 and 8 d after 131I administration in both famotidine- and promethazine-treated rats. Esomeprazole did not affect salivary gland uptake of radioiodine. *Statistically significant differences between drug-treated and control rats.
- FIGURE 3.
Effect of drug treatment on 131I uptake by stomach. Shown are effects of treatment with H1 receptor antagonist (promethazine), H2 receptor antagonist (famotidine), and PPI (esomeprazole) on uptake of 131I (NaI) by (empty) stomach in rat at 1 d (white bars) and 8 d (black bars) after intraperitoneal administration of radioiodine. Rat cohorts received either no additional drug (controls) or subcutaneous injections of specific drug (famotidine, promethazine, or esomeprazole) commencing 1 d before 131I (NaI) administration and continuing daily thereafter until day of euthanasia (1 or 8 d after radioiodine administration). White and black bars denote mean uptake value (%ID/g) of radioiodine per cohort (n = 8 for each cohort). Error bars represent SEM. Compared with untreated control rats, statistically significant increases in radioiodine uptake by stomach occurred at both 1 and 8 d after 131I administration only in promethazine-treated rats. Treatment with esomeprazole and famotidine did not alter gastric radioiodine uptake. *Statistically significant differences between drug-treated and control rats.
- FIGURE 4.
Effect of drug treatment on 131I uptake by liver. Shown are effects of treatment with H1 receptor antagonist (promethazine), H2 receptor antagonist (famotidine), and PPI (esomeprazole) on uptake of 131I (NaI) by liver in rat at 1 d (white bars) and 8 d (black bars) after intraperitoneal administration of radioiodine. Rat cohorts received either no additional drug (controls) or subcutaneous injections of specific drug (famotidine, promethazine, or esomeprazole) commencing 1 d before 131I (NaI) administration and continuing daily thereafter until day of euthanasia (1 or 8 d after radioiodine administration). White and black bars denote mean uptake value (%ID/g) of radioiodine per cohort (n = 8 for each cohort). Error bars represent SEM. Compared with untreated control rats, statistically significant decreases in radioiodine uptake by liver occurred at 1 d after 131I administration in both famotidine- and promethazine-treated rats. At 8 d after 131I administration, opposite pattern occurred, with significant increase in hepatic uptake of 131I in famotidine- and promethazine-treated rats, compared with controls. Esomeprazole did not alter hepatic radioiodine uptake. *Statistically significant differences between drug-treated and control rats.
- FIGURE 5.
Effect of drug treatment on 131I uptake by whole blood. Shown are effects of treatment with H1 receptor antagonist (promethazine), H2 receptor antagonist (famotidine), and PPI (esomeprazole) on uptake of 131I (NaI) by whole blood in rat at 1 d (white bars) and 8 d (black bars) after intraperitoneal administration of radioiodine. Rat cohorts received either no additional drug (controls) or subcutaneous injections of specific drug (famotidine, promethazine, or esomeprazole) commencing 1 d before 131I (NaI) administration and continuing daily thereafter until day of euthanasia (1 or 8 d after radioiodine administration). White and black bars denote mean uptake value (%ID/g) of radioiodine per cohort (n = 8 for each cohort). Error bars represent SEM. When compared with control rats, no significant differences were noted in content of 131I in whole-blood samples for rats treated with any of the 3 drugs either at 1 or at 8 d after radioiodine administration.
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