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Research ArticleImaging

A Monte Carlo Study of the Dependence of Early Frame Sampling on Uncertainty and Bias in Pharmacokinetic Parameters from Dynamic PET

Ida Häggström, Jan Axelsson, Charles Ross Schmidtlein, Mikael Karlsson, Anders Garpebring, Lennart Johansson, Jens Sörensen and Anne Larsson
Journal of Nuclear Medicine Technology March 2015, 43 (1) 53-60; DOI: https://doi.org/10.2967/jnmt.114.141754
Ida Häggström
1Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Jan Axelsson
1Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Charles Ross Schmidtlein
2Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York; and
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Mikael Karlsson
1Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Anders Garpebring
1Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Lennart Johansson
1Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Jens Sörensen
3Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden
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Anne Larsson
1Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Article Information

vol. 43 no. 1 53-60
DOI 
https://doi.org/10.2967/jnmt.114.141754
PubMed 
25613339

Published By 
Society of Nuclear Medicine
Print ISSN 
0091-4916
Online ISSN 
1535-5675
History 
  • Received for publication April 15, 2014
  • Accepted for publication November 19, 2014
  • Published online March 4, 2015.

Article Versions

  • previous version (January 22, 2015 - 05:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Ida Häggström1,
  2. Jan Axelsson1,
  3. Charles Ross Schmidtlein2,
  4. Mikael Karlsson1,
  5. Anders Garpebring1,
  6. Lennart Johansson1,
  7. Jens Sörensen3 and
  8. Anne Larsson1
  1. 1Department of Radiation Sciences, Umeå University, Umeå, Sweden
  2. 2Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York; and
  3. 3Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden
  1. For correspondence or reprints contact: Ida Häggström, Department of Radiation Sciences, Radiation Physics, Umeå University, SE-901 87 Umeå, Sweden. E-mail: ida.haggstrom@radfys.umu.se
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Journal of Nuclear Medicine Technology: 43 (1)
Journal of Nuclear Medicine Technology
Vol. 43, Issue 1
March 1, 2015
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A Monte Carlo Study of the Dependence of Early Frame Sampling on Uncertainty and Bias in Pharmacokinetic Parameters from Dynamic PET
Ida Häggström, Jan Axelsson, Charles Ross Schmidtlein, Mikael Karlsson, Anders Garpebring, Lennart Johansson, Jens Sörensen, Anne Larsson
Journal of Nuclear Medicine Technology Mar 2015, 43 (1) 53-60; DOI: 10.2967/jnmt.114.141754
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Keywords

  • Dynamic PET
  • Monte Carlo
  • GATE
  • compartment modeling
  • frame sampling
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A Monte Carlo Study of the Dependence of Early Frame Sampling on Uncertainty and Bias in Pharmacokinetic Parameters from Dynamic PET
Ida Häggström, Jan Axelsson, Charles Ross Schmidtlein, Mikael Karlsson, Anders Garpebring, Lennart Johansson, Jens Sörensen, Anne Larsson
Journal of Nuclear Medicine Technology Mar 2015, 43 (1) 53-60; DOI: 10.2967/jnmt.114.141754

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