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Research ArticleImaging

Lesion Detection Performance: Comparative Analysis of Low-Dose CT Data of the Chest on Two Hybrid Imaging Systems

Maryam Jessop, John D. Thompson, Joanne Coward, Audun Sanderud, José Jorge, Martijn de Groot, Luís Lança and Peter Hogg
Journal of Nuclear Medicine Technology March 2015, 43 (1) 47-52; DOI: https://doi.org/10.2967/jnmt.114.147447
Maryam Jessop
1University of Salford, Manchester, United Kingdom
2Brighton and Sussex University Hospitals, NHS Trust, Brighton, United Kingdom
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John D. Thompson
1University of Salford, Manchester, United Kingdom
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Joanne Coward
1University of Salford, Manchester, United Kingdom
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Audun Sanderud
3Oslo and Akershus University College of Applied Sciences, Oslo, Norway
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José Jorge
4Haute École de Santé Vaud, HES-SO, Lausanne, Switzerland
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Martijn de Groot
5Hanze University of Applied Sciences, Groningen, The Netherlands; and
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Luís Lança
6Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL), Lisbon, Portugal
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Peter Hogg
1University of Salford, Manchester, United Kingdom
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  • FIGURE 1.
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    FIGURE 1.

    Symbia T6 (A) and Infinia Hawkeye 4 (B) images.

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    FIGURE 2.

    Interpreter-averaged alternative FROC curves for both treatments.

  • FIGURE 3.
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    FIGURE 3.

    Symbia T6 lesion detection data expressed as percentage of interpreters who detected the lesion (averaged over cases) with overall average true-positive confidence ratings for each. Lesion identification (ID) on x-axis describes lesion density (HU) and size groupings.

  • FIGURE 4.
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    FIGURE 4.

    Infinia Hawkeye 4 lesion detection data expressed as percentage of interpreters who detected the lesion (averaged over cases) with overall average true-positive confidence ratings for each. Lesion identification (ID) on x-axis describes lesion density (HU) and size groupings.

Tables

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    TABLE 1

    The Acquisition Settings Used for CTAC

    SystemkVpEffective mAsSlice configurationMatrix sizeScan FOV (mm)Display FOV (mm)Pixel size (mm)Reconstruction kernels
    Symbia T613013.86 × 3 mm512 × 5125002820.55B08s, B30s, B60s
    Hawkeye 414023.74 × 5 mm256 × 2565654351.70Defined
    • FOV = field of view.

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    TABLE 2

    Data for Each System Alone and for the Two Compared

    SystemJAFROC figure-of-merit valueSD95% confidence interval
    Symbia T6 alone0.8100.0140.781, 0.839
    Hawkeye 4 alone0.5990.0150.568, 0.631
    Difference0.2110.0140.182, 0.240
    • View popup
    TABLE 3

    Lesion Detection Data Averaged over Cases

    Lesion detailsNo. interpreters (S-T6)True-positive rating (S-T6)No. interpreters (IH-4)True-positive rating (IH-4)
    12 mm +100 HU21.6678.6121.6677.477
    12 mm −630 HU217.968166.415
    12 mm −800 HU21.3337.973.6673.637
    10 mm +100 HU218.08216.567
    10 mm −630 HU19.756.9337.753.43
    10 mm −800 HU187.03582.765
    8 mm +100 HU15.55.8581.75
    8 mm −630 HU186.6829.62.488
    8 mm −800 HU15.3336.40712.667
    5 mm +100 HU8.3334.9573.6671.15
    5 mm −630 HU9.754.23.251.308
    5 mm −800 HU3.6661.2400
    • S-T6 = Symbia T6; IH-4 = Infinia Hawkeye 4.

    • Total number of interpreters was 22.

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Journal of Nuclear Medicine Technology: 43 (1)
Journal of Nuclear Medicine Technology
Vol. 43, Issue 1
March 1, 2015
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Lesion Detection Performance: Comparative Analysis of Low-Dose CT Data of the Chest on Two Hybrid Imaging Systems
Maryam Jessop, John D. Thompson, Joanne Coward, Audun Sanderud, José Jorge, Martijn de Groot, Luís Lança, Peter Hogg
Journal of Nuclear Medicine Technology Mar 2015, 43 (1) 47-52; DOI: 10.2967/jnmt.114.147447
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Keywords

  • JAFROC
  • Observer performance
  • Low-dose CT
  • CTAC
  • Incidental findings
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Lesion Detection Performance: Comparative Analysis of Low-Dose CT Data of the Chest on Two Hybrid Imaging Systems
Maryam Jessop, John D. Thompson, Joanne Coward, Audun Sanderud, José Jorge, Martijn de Groot, Luís Lança, Peter Hogg
Journal of Nuclear Medicine Technology Mar 2015, 43 (1) 47-52; DOI: 10.2967/jnmt.114.147447

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