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Research ArticleImaging

Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging

Michael K. O’Connor, Carrie B. Hruska, Thuy D. Tran, Tiffinee Swanson, Amy Lynn Conners, Katie Jones and Deborah J. Rhodes
Journal of Nuclear Medicine Technology March 2015, 43 (1) 13-20; DOI: https://doi.org/10.2967/jnmt.114.150128
Michael K. O’Connor
1Department of Radiology, Mayo Clinic, Rochester, Minnesota
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Carrie B. Hruska
1Department of Radiology, Mayo Clinic, Rochester, Minnesota
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Thuy D. Tran
1Department of Radiology, Mayo Clinic, Rochester, Minnesota
CNMT
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Tiffinee Swanson
1Department of Radiology, Mayo Clinic, Rochester, Minnesota
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Amy Lynn Conners
1Department of Radiology, Mayo Clinic, Rochester, Minnesota
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Katie Jones
1Department of Radiology, Mayo Clinic, Rochester, Minnesota
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Deborah J. Rhodes
2Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota
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  • FIGURE 1.
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    FIGURE 1.

    Upper and lower left MLO images from subject in group 1 after initial injection (A and B) of 99mTc-sestamibi and immediately before (C and D) and after (E and F) second injection of 99mTc-sestamibi. Identical ROI was copied onto all images for measurement of count density.

  • FIGURE 2.
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    FIGURE 2.

    Relationship between measured biologic washout factor of 99mTc-sestamibi and interval between imaging of subjects in groups 1 and 3.

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    FIGURE 3.

    Relationship between count density in all participating subjects, assessed in fasting state, and body surface area.

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    FIGURE 4.

    Relationship between count density, assessed in fasting state in all participating subjects, and breast density assessed from most recent mammogram.

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    FIGURE 5.

    Correlation between count density in breast from subjects in group 1 in fasting and fed states. Dotted line = line of identity.

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    FIGURE 6.

    (A) Average percentage increase in breast count density between fasting and fed states for subjects in group 1. (B) Average percentage increase in breast count density between subjects before and after peripheral warming (group 3).

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    FIGURE 7.

    Summary of count density in breast for subjects in each of the 4 study groups and those in reference group.

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    TABLE 1

    Summary of Breast Activity in the 4 Groups and Reference Group

    Breast activity (counts/cm2/MBq)
    Percentile
    GroupStatenMeanSDMedian10th90thP
    1Fasting258.332.547.765.6112.800.014
    Fed6.592.256.224.1810.29
    2Fasting/rest2510.142.7910.736.1514.07<0.001
    Fasting/exercise6.631.586.404.488.99
    3Fasting528.542.368.305.6212.150.38
    Fasting/caffeine8.132.318.165.1910.89
    4Fasting/cold529.132.348.636.3612.17<0.001
    Fasting/warm10.862.7110.467.4915.56
    All fasting studies1548.962.518.575.9512.36<0.001
    Reference group607.081.926.814.929.88
    • Reference group vs. fed group, P = 0.49.

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Journal of Nuclear Medicine Technology: 43 (1)
Journal of Nuclear Medicine Technology
Vol. 43, Issue 1
March 1, 2015
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Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
Michael K. O’Connor, Carrie B. Hruska, Thuy D. Tran, Tiffinee Swanson, Amy Lynn Conners, Katie Jones, Deborah J. Rhodes
Journal of Nuclear Medicine Technology Mar 2015, 43 (1) 13-20; DOI: 10.2967/jnmt.114.150128

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Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
Michael K. O’Connor, Carrie B. Hruska, Thuy D. Tran, Tiffinee Swanson, Amy Lynn Conners, Katie Jones, Deborah J. Rhodes
Journal of Nuclear Medicine Technology Mar 2015, 43 (1) 13-20; DOI: 10.2967/jnmt.114.150128
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