PT  - JOURNAL ARTICLE
AU  - Michael K. O’Connor
AU  - Carrie B. Hruska
AU  - Thuy D. Tran
AU  - Tiffinee Swanson
AU  - Amy Lynn Conners
AU  - Katie Jones
AU  - Deborah J. Rhodes
TI  - Factors Influencing the Uptake of <sup>99m</sup>Tc-Sestamibi in Breast Tissue on Molecular Breast Imaging
AID  - 10.2967/jnmt.114.150128
DP  - 2015 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 13--20
VI  - 43
IP  - 1
4099  - http://tech.snmjournals.org/content/43/1/13.short
4100  - http://tech.snmjournals.org/content/43/1/13.full
SO  - J. Nucl. Med. Technol.2015 Mar 01; 43
AB  - The purpose of this study was to evaluate the impact of changes to a patient’s prandial status, metabolic status (rest vs. exercise), and peripheral blood flow (via caffeine or warming) on the uptake of 99mTc-sestamibi in breast tissue. Methods: A total of 154 subjects participated in 1 of 4 study groups that evaluated the effects of 4 types of intervention on the uptake of 99mTc-sestamibi in breast tissue (effect of fasting, light exercise, caffeine, and peripheral warming). Molecular breast imaging was performed before and after each intervention. Count density was assessed in counts/cm2/MBq from the mediolateral oblique view in all studies. Results: Uptake of 99mTc-sestamibi in breast tissue increased by approximately 25% from 6.6 counts/cm2/MBq in the fed state to 8.3 counts/cm2/MBq with fasting. Peripheral warming also resulted in an approximately 20% increase in count density from 9.1 to 10.9 counts/cm2/MBq. Conversely, exercise caused a 35% drop in count density relative to the resting state. Uptake did not seem to be influenced by caffeine and did not correlate with a patient’s height, weight, or breast thickness. There was only a weak correlation between breast activity and body surface area. Conclusion: The combined effects of fasting and warming resulted in an approximately 50% increased uptake of 99mTc-sestamibi in breast tissue relative to that observed in a reference group to whom no preparatory instructions had been given. Optimal patient preparation before administration of 99mTc-sestamibi should permit a corresponding reduction in either acquisition time or required dose of 99mTc-sestamibi.