Research ArticleImaging

Comparison of a Free-Breathing CT and an Expiratory Breath-Hold CT with Regard to Spatial Alignment of Amplitude-Based Respiratory-Gated PET and CT Images

Charlotte S. van der Vos, Willem Grootjans, Antoi P.W. Meeuwis, Cornelis H. Slump, Wim J.G. Oyen, Lioe-Fee F. de Geus-Oei and Eric P. Visser
Journal of Nuclear Medicine Technology December 2014, 42 (4) 269-273; DOI: https://doi.org/10.2967/jnmt.114.145748

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Coronal respiratory-gated PET images. (A) Patient with squamous cell carcinoma in FB group. Lesion delineation using PET (green) and CT (red). Difference between centroids of PET and CT images is 10.5 mm. JSC is 0.29. (B) Patient with adenocarcinoma in BH group. PET lesion delineation is green, and CT delineation is red. Difference between centroids of PET and CT images is 4.0 mm; JSC is 0.50.

  • FIGURE 2.
    FIGURE 2.

    Distribution between difference of centroids between PET and CT scan. There are several outliers, depicted as ○, which are values that do not fall in inner fences, and even extreme outliers (*), which are more than 3 times height of boxes. UL = upper lobes; MLL = middle and lower lobes; hilum = central lesions, connected to hilum of lung.

  • FIGURE 3.
    FIGURE 3.

    Distribution of JSC for both FB and BH groups for 3 localizations. There are several outliers (values that do not fall in inner fences). UL = upper lobes; MLL = middle and lower lobes; hilum = central lesions, connected to hilum of lung.

Tables

  • TABLE 1

    Demographics of Patient Population

    CharacteristicFB groupBH group
    Average age in y66.7 (9.5)70.9 (9.8)
    Average weight in kg77.7 (12.1)70.6 (11.9)
    Sex
     Female126
     Male2410
    Confirmed malignancy
     Primary lung cancer2510
     Metastasis33
     Other and unconfirmed83
    Lesion size on CT in mm38,261.6 (22,914.4)8,890.2 (21,872.8)
    Average 18F-FDG dose in MBq247.7 (40.2)225.8 (41.5)
    Minimum SUVmax in g/cm30.671.03

    • Data in parentheses are SDs.

    • SUVmax = maximum SUV.

  • TABLE 2

    Number of Lesions for FB and BH Groups

    Anatomic locationFB groupBH group
    Upper lobes4517
    Middle and lower lobes3019
    Central113
    Total8639
  • TABLE 3

    Results of Distance of Centroids Between PET and CT Images

    LocationFB group (mm)BH group (mm)P
    Upper lobes4.7 ± 3.16.0 ± 3.00.11
    Middle and lower lobes5.8 ± 4.35.1 ± 2.90.70
    Central4.8 ± 4.65.6 ± 2.00.24
    Total5.1 ± 3.85.5 ± 2.90.16
  • TABLE 4

    Results of JSC

    LocationFB groupBH groupP
    Upper lobes0.28 ± 0.170.28 ± 0.190.83
    Middle and lower lobes0.22 ± 0.160.28 ± 0.180.20
    Central0.39 ± 0.170.13 ± 0.040.04
    Total0.27 ± 0.170.27 ± 0.180.95
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