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Research ArticleImaging

Subcentimeter Tumor Lesion Delineation for High-Resolution 18F-FDG PET Images: Optimizing Correction for Partial-Volume Effects

Elin Wallstén, Jan Axelsson, Torbjörn Sundström, Katrine Riklund and Anne Larsson
Journal of Nuclear Medicine Technology June 2013, 41 (2) 85-91; DOI: https://doi.org/10.2967/jnmt.112.117234
Elin Wallstén
Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Jan Axelsson
Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Torbjörn Sundström
Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Katrine Riklund
Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Anne Larsson
Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Article Figures & Data

Figures

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  • FIGURE 1.
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    FIGURE 1.

    All balloons in phantom.

  • FIGURE 2.
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    FIGURE 2.

    Balloons attached to syringes, which are inserted through holes in lid of phantom. When lid is mounted on phantom, syringes hang from top of phantom, with balloons a few centimeters from bottom of box.

  • FIGURE 3.
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    FIGURE 3.

    Comparison of methods for volume delineation, using either Imean or I′mean in Equation 1. (A) Relative volume error for ratio of 4.1. (B) Corresponding results for ratio of 6.0.

  • FIGURE 4.
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    FIGURE 4.

    Volume estimates for activity ratios of 4.1, 9.1, and 14.9. (A) Results for images reconstructed with SharpIR. (B) Results for images reconstructed with VP HD. Ratios of 4.1 and 9.1 are slightly shifted to left to improve clarity.

  • FIGURE 5.
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    FIGURE 5.

    Uptake estimates for activity ratios 4.1, 9.1, and 14.9 before and after partial-volume corrections, and compared with maximum uptake value. Original uptake and corrected uptake are shifted slightly to left to improve clarity.

Tables

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    TABLE 1

    Balloon Volumes and Dimensions

    Volume (mL)Diameter (mm)Height (mm)Equivalent diameter (mm)
    0.113676.0
    0.208787.4
    0.3528108.8
    0.4818129.7
    0.698101511.0
    • View popup
    TABLE 2

    Optimal Value of ε for All Activity Ratios

    Activity ratioVP HDSharpIR
    4.10.3000.250
    6.00.3250.275
    9.10.3500.300
    12.50.3750.300
    14.90.3750.300
    No background0.4250.275
    Mean0.3500.275
    • Mean value is rounded to closest of tested values.

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Journal of Nuclear Medicine Technology: 41 (2)
Journal of Nuclear Medicine Technology
Vol. 41, Issue 2
June 1, 2013
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Subcentimeter Tumor Lesion Delineation for High-Resolution 18F-FDG PET Images: Optimizing Correction for Partial-Volume Effects
Elin Wallstén, Jan Axelsson, Torbjörn Sundström, Katrine Riklund, Anne Larsson
Journal of Nuclear Medicine Technology Jun 2013, 41 (2) 85-91; DOI: 10.2967/jnmt.112.117234
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Keywords

  • PET
  • partial-volume effects
  • partial volume correction
  • volume delineation
  • resolution recovery
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Subcentimeter Tumor Lesion Delineation for High-Resolution 18F-FDG PET Images: Optimizing Correction for Partial-Volume Effects
Elin Wallstén, Jan Axelsson, Torbjörn Sundström, Katrine Riklund, Anne Larsson
Journal of Nuclear Medicine Technology Jun 2013, 41 (2) 85-91; DOI: 10.2967/jnmt.112.117234

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