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Research ArticleContinuing Education

Assessment of Glomerular Filtration Rate Measurement with Plasma Sampling: A Technical Review

Anthony W. Murray, Mark C. Barnfield, Michael L. Waller, Tania Telford and A. Michael Peters
Journal of Nuclear Medicine Technology June 2013, 41 (2) 67-75; DOI: https://doi.org/10.2967/jnmt.113.121004
Anthony W. Murray
1Department of Medical Physics, St. James’s University Hospital, Leeds, United Kingdom; and
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Mark C. Barnfield
1Department of Medical Physics, St. James’s University Hospital, Leeds, United Kingdom; and
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Michael L. Waller
1Department of Medical Physics, St. James’s University Hospital, Leeds, United Kingdom; and
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Tania Telford
1Department of Medical Physics, St. James’s University Hospital, Leeds, United Kingdom; and
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A. Michael Peters
2Department of Nuclear Medicine, Royal Sussex County Hospital, Brighton, United Kingdom
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  • FIGURE 1.
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    FIGURE 1.

    The 4 stages of radionuclide-based GFR studies.

  • FIGURE 2.
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    FIGURE 2.

    Two- and 3-compartment models with respective rate constants, kij. K10 is taken to be GFR clearance. Two-compartment model views compartment 1 as intravascular volume and compartment 2 as extravascular volume. Compartment 3 is considered to be present in patients with known third fluid compartments.

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    FIGURE 3.

    Example of 9-sample (5, 10, 20, 60, 120, 180, 240, 360, and 480 min) plasma clearance for a given dose of 99mTc-DTPA. (A) Plot of plasma sample counting rate vs. time (black dots) with fitted biexponential curve. (B) Part A with individual early and late exponential curves. (C) Linear fits for natural logarithm of early and late exponentials.

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    TABLE 1

    Maximum Suggested Adult and Pediatric Administered and Effective Doses Relating to Undergoing GFR Measurement Study with 51Cr-EDTA and 99mTc-DTPA

    U.K.: ARSAC notes for guidance (adults)EANM guidelines (pediatric)
    TracerAdministered dose (MBq)Effective dose (mSv)Administered dose (MBq)Effective dose (mSv)
    51Cr-EDTA30.0063.70.011
    99mTc-DTPA100.06370.1
    • ARSAC = Administration of Radioactive Substances Advisory Committee (U.K. advisory committee).

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Journal of Nuclear Medicine Technology: 41 (2)
Journal of Nuclear Medicine Technology
Vol. 41, Issue 2
June 1, 2013
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Assessment of Glomerular Filtration Rate Measurement with Plasma Sampling: A Technical Review
Anthony W. Murray, Mark C. Barnfield, Michael L. Waller, Tania Telford, A. Michael Peters
Journal of Nuclear Medicine Technology Jun 2013, 41 (2) 67-75; DOI: 10.2967/jnmt.113.121004

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Assessment of Glomerular Filtration Rate Measurement with Plasma Sampling: A Technical Review
Anthony W. Murray, Mark C. Barnfield, Michael L. Waller, Tania Telford, A. Michael Peters
Journal of Nuclear Medicine Technology Jun 2013, 41 (2) 67-75; DOI: 10.2967/jnmt.113.121004
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  • Article
    • Abstract
    • PRACTICALITIES OF GFR MEASUREMENT
    • CLINICAL CONSIDERATIONS
    • RADIONUCILIDE-BASED TRACERS
    • CLEARANCE CHARACTERIZATION
    • GFR NORMALIZATION
    • GFR AND CHEMOTHERAPY
    • CONCLUSION
    • DISCLOSURE
    • Acknowledgments
    • Footnotes
    • REFERENCES
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  • Comparison of Performance of Improved Serum Estimators of Glomerular Filtration Rate (GFR) to 99mTc-DTPA GFR Methods in Patients with Hepatic Cirrhosis
  • Radionuclides in Nephrourology, Part 1: Radiopharmaceuticals, Quality Control, and Quantitative Indices
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Keywords

  • GFR measurement
  • Glomerular Filtration Rate
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  • GFR normalization
  • technical review
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