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Research ArticleIMAGING

Stability Evaluation of 18F-FDG at High Radioactive Concentrations

Leah R. Walters, Katherine J. Martin, Mark S. Jacobson, Joseph C. Hung and Elton A. Mosman
Journal of Nuclear Medicine Technology March 2012, 40 (1) 52-56; DOI: https://doi.org/10.2967/jnmt.111.097287
Leah R. Walters
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Katherine J. Martin
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Mark S. Jacobson
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Joseph C. Hung
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Elton A. Mosman
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    FIGURE 1.

    Radiolytic decomposition profile for 18F-FDG with radioactive concentrations of 19.7–22.6 GBq/mL (533–610 mCi/mL) doped with ethanol concentrations of 0%, 0.1%, and 0.2%. Horizontal solid line represents 10.0% threshold for amount of 18F− impurities in solution.

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    TABLE 1

    Relationship of 18F−-Fluoride Contents at EOS and Final Hour Versus Various Ethanol and Radioactive Concentrations

    Ethanol concentration (% w/v)Radioactive concentration at EOS*Percentage of 18F−-fluoride content …
    mCi/mLGBq/mLEOSFinal hour†
    0.00563.3320.843.731.8 (7)
    0.00559.3320.705.228.1 (4)
    0.00599.7622.193.926.5 (4)
    0.10539.3519.962.710.9 (12)
    0.09596.8822.084.110.5 (12)
    0.12540.0019.981.911.8 (12)
    0.21555.1720.543.06.8 (12)
    0.21533.6019.741.96.1 (12)
    0.21609.1022.542.76.2 (12)
    • ↵* Solutions in 15-mL final volume.

    • ↵† Final hour is in parentheses.

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Journal of Nuclear Medicine Technology: 40 (1)
Journal of Nuclear Medicine Technology
Vol. 40, Issue 1
March 1, 2012
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Stability Evaluation of 18F-FDG at High Radioactive Concentrations
Leah R. Walters, Katherine J. Martin, Mark S. Jacobson, Joseph C. Hung, Elton A. Mosman
Journal of Nuclear Medicine Technology Mar 2012, 40 (1) 52-56; DOI: 10.2967/jnmt.111.097287

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Stability Evaluation of 18F-FDG at High Radioactive Concentrations
Leah R. Walters, Katherine J. Martin, Mark S. Jacobson, Joseph C. Hung, Elton A. Mosman
Journal of Nuclear Medicine Technology Mar 2012, 40 (1) 52-56; DOI: 10.2967/jnmt.111.097287
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