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Research ArticleIMAGING

Influence of Reconstruction Parameters During Filtered Backprojection and Ordered-Subset Expectation Maximization in the Measurement of the Left-Ventricular Volumes and Function During Gated SPECT

Diana D. Duarte, Marina S. Monteiro, Fatima El Hakmaoui, John O. Prior, Lina Vieira and José A. Pires-Jorge
Journal of Nuclear Medicine Technology March 2012, 40 (1) 29-36; DOI: https://doi.org/10.2967/jnmt.111.094599
Diana D. Duarte
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Marina S. Monteiro
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Fatima El Hakmaoui
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John O. Prior
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Lina Vieira
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José A. Pires-Jorge
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  • FIGURE 1.
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    FIGURE 1.

    Scheme of beating-heart phantom: LV of heart is simulated by double-elastic membrane forming inner cavity filled with distilled water and outer cavity filled with air. Interior compartment represents ventricular cavity, and inside of double membrane represents cardiac wall and is filled with radioactive solution. Pumping unit guarantees periodic expansion of interior compartment, allowing volume changes of this cavity simulating cardiac cycle.

  • FIGURE 2.
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    FIGURE 2.

    Effect of order on difference from true value of LVEF and value measured (%) and cutoff frequency in FBP reconstruction.

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    FIGURE 3.

    Effect of number of subsets on difference from true value of LVEF and value measured (error) and number of iterations in OSEM reconstruction.

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    FIGURE 4.

    Effect of number of EM equivalent iterations on difference from true value of volumes and ejection fraction of LV and value measured (error) in OSEM reconstruction.

Tables

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    TABLE 1

    Results from FBP Reconstruction

    EDVESVSVLVEF
    Cutoff frequencyRange (mL)Mean ± SDρRange (mL)Mean ± SDρRange (mL)Mean ± SDρRange (%)Mean ± SDρ
    0.251–6155.0 ± 4.24−0.6332–105.3 ± 3.40−0.40049–5149.8 ± 0.96−0.949*84–9791.0 ± 5.480.400
    0.377–7877.5 ± 0.580.44719–2120.0 ± 0.820.949*57–5857.5 ± 0.58−0.89473–7674.3 ± 1.26−0.949*
    0.484–8685.0 ± 0.820.31623–2524.3 ± 0.960.31660–6160.8 ± 0.50−0.25871–7371.5 ± 1.00−0.775
    0.586–8887.3 ± 0.960.949*24–2524.5 ± 0.580.00062–6462.8 ± 0.96−0.949*71–7271.3 ± 0.50−0.775
    0.685–8786.3 ± 0.96−0.31624–2524.8 ± 0.50−0.77561–6261.5 ± 0.58−0.0007171.0 ± 0.00—
    0.785–8685.8 ± 0.50−0.25824–2524.8 ± 0.50−0.2586161.0 ± 0.00—7171.0 ± 0.00—
    0.886–8786.5 ± 0.58−0.4472525.0 ± 0.00—61–6261.5 ± 0.580.4477171.0 ± 0.00—
    • ↵* Correlations are significant when P ≤ 0.05.

    • View popup
    TABLE 2

    Results from OSEM Reconstruction

    EDVESVSVLVEF
    No. of subsetsRange (mL)Mean ± SDρRange (mL)Mean ± SDρRange (mL)Mean ± SDρRange (%)Mean ± SDρ
    261–9582.8 ± 11.221.00*10–3225.1 ± 7.470.99*51–6357.7 ± 3.870.99*66–8370.6 ± 5.85−0.99*
    470–9688.9 ± 8.311.00*16–3328.8 ± 5.420.99*54–6360.1 ± 2.940.98*65–7767.9 ± 3.62−0.95*
    672–9689.2 ± 7.680.97*17–3329.0 ± 5.030.95*55–6460.2 ± 2.820.92*66–7667.8 ± 3.27−0.86*
    883–9592.7 ± 3.900.6926–3331.4 ± 2.300.69*57–6361.2 ± 1.790.4865–6966.0 ± 1.32−0.63
    1083–9592.6 ± 3.700.7226–3331.6 ± 2.180.5157–6261.0 ± 1.580.84*65–6966.0 ± 1.23−0.37
    1283–9692.8 ± 4.060.82*26–3331.6 ± 2.300.75*57–6361.2 ± 1.790.86*65–6966.2 ± 1.20−0.91*
    1692–9694.2 ± 1.200.5231–3332.1 ± 0.600.5261–6362.1 ± 0.610.5265–6765.9 ± 0.60−0.52
    • ↵* Correlations are significant when P ≤ 0.05.

    • View popup
    TABLE 3

    Results from EM Equivalent Iterations

    EM equivalent iterations (I × S)EDV (mL)ESV (mL)SV (mL)LVEF (%)
    1278235571
    1481245770
    1683265769
    1879225771
    2083265769
    2283265769
    2488295967
    2683265769
    2890306067
    3086285867
    3290306067
    Mean84.0026.3657.6468.73
    SD4.072.691.501.56
    ρ0.867*0.839*0.835*−0.860*
    • ↵* Correlations are significant when P ≤ 0.05.

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Journal of Nuclear Medicine Technology: 40 (1)
Journal of Nuclear Medicine Technology
Vol. 40, Issue 1
March 1, 2012
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Influence of Reconstruction Parameters During Filtered Backprojection and Ordered-Subset Expectation Maximization in the Measurement of the Left-Ventricular Volumes and Function During Gated SPECT
Diana D. Duarte, Marina S. Monteiro, Fatima El Hakmaoui, John O. Prior, Lina Vieira, José A. Pires-Jorge
Journal of Nuclear Medicine Technology Mar 2012, 40 (1) 29-36; DOI: 10.2967/jnmt.111.094599

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Influence of Reconstruction Parameters During Filtered Backprojection and Ordered-Subset Expectation Maximization in the Measurement of the Left-Ventricular Volumes and Function During Gated SPECT
Diana D. Duarte, Marina S. Monteiro, Fatima El Hakmaoui, John O. Prior, Lina Vieira, José A. Pires-Jorge
Journal of Nuclear Medicine Technology Mar 2012, 40 (1) 29-36; DOI: 10.2967/jnmt.111.094599
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