Article Figures & Data
Figures
- FIGURE 1.
Axial slices over liver: CT image (top left), PET image (top right), PET/CT merged image (bottom left), and maximum-intensity projection (bottom right). Circular region of interest 5–10 cm in diameter, depending on patient, was positioned over normal liver in 3 contiguous slices that were similar in each static or dynamic frame.
- FIGURE 2.
Time–activity curves for patient 3 (Table 1). Data are not corrected for 18F physical decay. 1 = experimental (1 + 10 data points) and theoretic (solid line; Eq. 4) whole liver tissue activity versus time (per tissue volume unit); 2 = theoretic time–activity curve of trapped 18F-FDG (Eq. 1); 3 = theoretic 18F-FDG time–activity curve in blood and reversible compartment.
- FIGURE 3.
(Solid line) Simulation of decay-corrected mean 18F-FDG liver activity vs. time (arbitrary unit), which is proportional to decay-corrected SUV(t). Mean values of 18F-FDG metabolism in normal liver over series were used. Vertical lines show 50- to 110-min time range between tracer injection and acquisition, in which SUV(t) is within 5% of peak value (t = 75–80 min). (Dotted line) Simulation of decay-corrected 18F-FDG activity vs. time of possibly malignant lesion with irreversible 18F-FDG trapping exactly matching that of normal liver tissue at 1 h after injection.
Tables
Patient no. (n = 11) Age (y) Weight (kg) Height (cm) Glycemia (g/L) Ainj (MBq) t1 (min) t2 (min) SUV1 (g/mL) SUV2 (g/mL) K (mL/min/mL) kR (/min) F (mL/mL) 1 49 59 167 1.03 294 65 130 2.27 1.75 0.0146 0.0083 0.35 2 61 70 180 0.97 285 68 131 2.26 1.82 0.0107 0.0063 0.36 3 66 64 172 0.91 320 58 158 2.46 1.88 0.0146 0.0068 0.29 4 66 80 180 0.96 384 55 152 2.25 1.77 0.0099 0.0059 0.25 5 82 62 165 0.98 291 76 148 2.15 1.83 0.0144 0.0066 0.10 6 70 90 180 0.99 394 61 149 1.78 1.42 0.0094 0.0085 0.03 7 48 94 181 1.26 437 88 160 2.93 2.52 0.0126 0.0062 0.09 8 67 41 150 0.80 215 89 175 2.02 1.75 0.0132 0.0025 0.67 9 55 90 156 0.92 460 79 194 2.84 2.13 0.0133 0.0062 0.02 10 57 82 170 0.98 428 77 176 2.03 1.46 0.0093 0.0060 0.15 11 39 95 160 0.89 426 78 172 1.96 1.45 0.0093 0.0082 0.05 Average ± SD 60 ± 12 75 ± 17 169 ± 11 0.97 ± 0.12 358 ± 80 72 ± 12 159 ± 20 2.27 ± 0.36 1.80 ± 0.32 0.0119 ± 0.0022 0.0065 ± 0.0016 0.21 ± 0.20
Supplemental Data
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