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Research ArticleIMAGING

Improved Quality of Pediatric 123I-MIBG Images with Medium-Energy Collimators

Erin R. Snay, S. Ted Treves and Frederic H. Fahey
Journal of Nuclear Medicine Technology June 2011, 39 (2) 100-104; DOI: https://doi.org/10.2967/jnmt.110.080309
Erin R. Snay
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S. Ted Treves
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Frederic H. Fahey
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Figures

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  • FIGURE 1.
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    FIGURE 1.

    This figure shows 3 γ-rays being emitted from a point source at top of figure. γ-ray labeled “Good Detection” passes right through collimator hole and will be properly localized directly below point source. γ-ray labeled “Stopped by septa” hits septa and interacts, presumably by photoelectric effect, in septum and thus does not reach scintillation crystal.However, γ-ray labeled “Septal Penetration Bad Detection” passes through septum, reaching scintillation crystal at wrong location, not directly below point source. Probability for septal penetration depends on energy of incident γ-ray and thickness of septum. d = hole diameter; L = hole length; t = thickness of interhole septa.

  • FIGURE 2.
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    FIGURE 2.

    This figure shows SPECT and planar images acquired with a tomographic phantom filled with 123I. The phantom was imaged with LEUHR, LEHR, and medium-energy (ME) collimators. On the images using low-energy collimators, many events are localized outside the boundary of the phantom because of septal penetration. Image quality is better for the medium-energy-collimator images than for low-energy-collimator images because of higher contrast and lower noise.

  • FIGURE 3.
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    FIGURE 3.

    Whole-body planar (A) and SPECT (B) images of 123I-MIBG study in a 7-y-old patient with stage 4 neuroblastoma. Images on left were acquired during initial visit when we were using LEUHR collimators, and those on right were acquired several months later when we had modified our acquisition protocol to use medium-energy (ME) collimators. SPECT images are anterior maximum-intensity-projection images. Results are similar to the phantom results. For both whole-body planar imaging and SPECT, images obtained using medium-energy collimators demonstrated less septal penetration (fewer counts outside patient), higher contrast, and less noise.

  • FIGURE 4.
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    FIGURE 4.

    Whole-body planar images of 123I-NaI study in a 17-y-old patient being evaluated for thyroid cancer. Images on left were acquired during initial visit when we were using LEUHR collimator, and those on right were acquired several months later when we had modified our acquisition protocol to use medium-energy (ME) collimator. Results are similar to the phantom results. Images obtained using medium-energy collimator demonstrated less septal penetration (fewer counts outside patient), higher contrast, and less noise.

Tables

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    TABLE 1

    γ-Ray Emissions from 123I (4)

    Energy (keV)γ-rays per decay
    1590.828
    2480.0007
    2810.0008
    3460.0013
    4400.0043
    5050.0031
    5290.0138
    5390.0038
    6250.0008
    6880.0003
    7360.0006
    7840.0006
    • View popup
    TABLE 2

    Characteristics of 3 Collimators

    ParameterLEUHRLEHRMedium-energy
    Septal thickness (mm)0.130.161.14
    Hole diameter (mm)1.161.112.94
    Hole length (mm)35.824.0540.64
    Extrinsic sensitivity (cpm/kBq)*2.705.468.38
    Spatial resolution (mm)4.66.410.8
    Septal penetration at 159 keV2.0%3.5%0.0%
    Septal penetration at 300 keV42%48%4.90%
    Septal penetration at 500 keV71%75%30%
    • ↵* At 140 keV.

    • View popup
    TABLE 3

    System Sensitivity (in Counts per Minute per Kilobecquerel) of 123I Versus Distance for LEUHR, LEHR, and Medium-Energy Collimators

    Distance (cm)LEUHRLEHRMedium-energy
    06.5914.328.00
    105.5112.307.97
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Journal of Nuclear Medicine Technology: 39 (2)
Journal of Nuclear Medicine Technology
Vol. 39, Issue 2
June 1, 2011
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Improved Quality of Pediatric 123I-MIBG Images with Medium-Energy Collimators
Erin R. Snay, S. Ted Treves, Frederic H. Fahey
Journal of Nuclear Medicine Technology Jun 2011, 39 (2) 100-104; DOI: 10.2967/jnmt.110.080309

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Improved Quality of Pediatric 123I-MIBG Images with Medium-Energy Collimators
Erin R. Snay, S. Ted Treves, Frederic H. Fahey
Journal of Nuclear Medicine Technology Jun 2011, 39 (2) 100-104; DOI: 10.2967/jnmt.110.080309
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