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Research ArticleBRIEF COMMUNICATION

An Alternative Method for Determining the Radiochemical Purity of 99mTc-Tetrofosmin

Kanak C. Amin, Sagar Patel, Aniruddha Doke and Gopal B. Saha
Journal of Nuclear Medicine Technology March 2011, 39 (1) 51-54; DOI: https://doi.org/10.2967/jnmt.110.080788
Kanak C. Amin
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Sagar Patel
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Aniruddha Doke
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Gopal B. Saha
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  • FIGURE 1.
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    FIGURE 1.

    Distribution of 99mTc components in 99mTc-tetrofosmin preparation on SA and SG strips.

  • FIGURE 2.
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    FIGURE 2.

    Cutting marks for the three 99mTc components on SA (A) and SG (B) strips.

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    FIGURE 3.

    Radiochemical purity of 99mTc-tetrofosmin obtained by SA and SG strips in 26 reconstituted samples.

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    TABLE 1

    Material Data for the Chromatographic Method

    ParameterManufacturer's methodAlternative method
    Chromatography stripSGSA
    Solvent35% acetone65% acetone
    65% dichloromethane35% dichloromethane
    Strip size2 × 20 cm1.5 × 11 cm
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    TABLE 2

    Average Rf Values of Different 99mTc Components in 99mTc-Tetrofosmin Preparation

    ComponentSG stripSA strip
    99mTc, free0.9–1.00.9–1.0
    99mTc, hydrolyzed0.0–0.20.0–0.2
    99mTc-tetrofosmin0.3–0.80.3–0.8
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Journal of Nuclear Medicine Technology: 39 (1)
Journal of Nuclear Medicine Technology
Vol. 39, Issue 1
March 1, 2011
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An Alternative Method for Determining the Radiochemical Purity of 99mTc-Tetrofosmin
Kanak C. Amin, Sagar Patel, Aniruddha Doke, Gopal B. Saha
Journal of Nuclear Medicine Technology Mar 2011, 39 (1) 51-54; DOI: 10.2967/jnmt.110.080788

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An Alternative Method for Determining the Radiochemical Purity of 99mTc-Tetrofosmin
Kanak C. Amin, Sagar Patel, Aniruddha Doke, Gopal B. Saha
Journal of Nuclear Medicine Technology Mar 2011, 39 (1) 51-54; DOI: 10.2967/jnmt.110.080788
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