RT Journal Article
SR Electronic
T1 An Alternative Method for Determining the Radiochemical Purity of <sup>99m</sup>Tc-Tetrofosmin
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 51
OP 54
DO 10.2967/jnmt.110.080788
VO 39
IS 1
A1 Kanak C. Amin
A1 Sagar Patel
A1 Aniruddha Doke
A1 Gopal B. Saha
YR 2011
UL http://tech.snmjournals.org/content/39/1/51.abstract
AB The instant thin-layer chromatographic method of determining the radiochemical purity of 99mTc-tetrofosmin recommended by the manufacturer uses a mixture of acetone and dichloromethane (35:65 v/v) as the solvent and a silica gel (SG) strip as the solid phase. Currently, SG strips are not available commercially and an alternative solid phase is needed. The present study reports that silicic acid strips are an appropriate substitute for SG strips for the chromatographic method using the same solvent mixture but mixed in a reverse ratio (65:35 v/v). The 2 methods yielded similar values (within 1 SD) of radiochemical purity for 99mTc-tetrofosmin.