PT  - JOURNAL ARTICLE
AU  - Kanak C. Amin
AU  - Sagar Patel
AU  - Aniruddha Doke
AU  - Gopal B. Saha
TI  - An Alternative Method for Determining the Radiochemical Purity of <sup>99m</sup>Tc-Tetrofosmin
AID  - 10.2967/jnmt.110.080788
DP  - 2011 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 51--54
VI  - 39
IP  - 1
4099  - http://tech.snmjournals.org/content/39/1/51.short
4100  - http://tech.snmjournals.org/content/39/1/51.full
SO  - J. Nucl. Med. Technol.2011 Mar 01; 39
AB  - The instant thin-layer chromatographic method of determining the radiochemical purity of 99mTc-tetrofosmin recommended by the manufacturer uses a mixture of acetone and dichloromethane (35:65 v/v) as the solvent and a silica gel (SG) strip as the solid phase. Currently, SG strips are not available commercially and an alternative solid phase is needed. The present study reports that silicic acid strips are an appropriate substitute for SG strips for the chromatographic method using the same solvent mixture but mixed in a reverse ratio (65:35 v/v). The 2 methods yielded similar values (within 1 SD) of radiochemical purity for 99mTc-tetrofosmin.