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A Probabilistic Approach to Delineating Functional Brain Regions

Jan Kalbitzer, Claus Svarer, Vibe G. Frokjaer, David Erritzoe, William F.C. Baaré, Jacob Madsen, Steen G. Hasselbalch and Gitte M. Knudsen
Journal of Nuclear Medicine Technology June 2009, 37 (2) 91-95; DOI: https://doi.org/10.2967/jnmt.108.054056

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    Three-dimensional overlay of MR image and parametric map of 11C-DASB PET image representing BPND to 5-HTT. BPND was thresholded until only activity in area of raphé nuclei was visible.

  • FIGURE 2. 
    FIGURE 2. 

    Creation of template: delineation of rostral raphé nuclei on parametric PET image by increasing threshold until no activity outside raphé area is included (A) and then transferring VOI to coregistered MR image (B).

  • FIGURE 3. 
    FIGURE 3. 

    Warping from several template MR images (n = 10) onto MR image of test subject creates probabilistic VOI (A); in second step, VOI is transferred from MR image of test subject to coregistered PET image (B).

  • FIGURE 4. 
    FIGURE 4. 

    BPND (A) and resulting χ2 (B) obtained using probabilistic VOI and VOI of 3 observers. Horizontal lines represent means, and bars indicate SD.

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