Article Figures & Data
Figures
- FIGURE 1.
Mean plasma ALP activity in control dogs, dogs receiving 177Lu-DOTMP, and dogs receiving 153Sm-EDTMP at 37 MBq/kg. Plasma ALP activity did not vary from baseline for dogs receiving 177Lu-DOTMP. Statistically significant differences in means were present on days 7 and 28 (asterisks). Biliary tract, bone, and corticosteroid-inducible ALP contributed to plasma ALP activity. Horizontal dashed line represents upper limit of laboratory reference interval at time of 177Lu-DOTMP experiment. *P < 0.05. IU = international units.
- FIGURE 2.
Mean plasma ALT activity in control dogs, dogs receiving 177Lu-DOTMP, and dogs receiving 153Sm-EDTMP at 37 MBq/kg. Plasma ALT activity did not vary from baseline for dogs receiving 177Lu-DOTMP, and activity remained within reference interval for all groups. Horizontal dashed line represents upper limit of laboratory reference interval at time of 177Lu-DOTMP experiment. IU = international units.
- FIGURE 3.
Mean plasma urea nitrogen levels in control dogs, dogs receiving 177Lu-DOTMP, and dogs receiving 153Sm-EDTMP at 37 MBq/kg. Plasma urea nitrogen activity did not vary from baseline for dogs receiving 177Lu-DOTMP, and activity was within reference interval for all groups. Horizontal dashed line represents upper limit of laboratory reference interval at time of 177Lu-DOTMP experiment.
- FIGURE 4.
Mean WBC counts in control dogs, dogs receiving 177Lu-DOTMP, and dogs receiving 153Sm-EDTMP at 37 MBq/kg. WBC counts did not vary from baseline for dogs receiving 177Lu-DOTMP, but statistically significant differences in means for other groups were present on days 14, 54, and 84 (asterisks). Horizontal dashed line represents lower limit of laboratory reference interval at time of 177Lu-DOTMP experiment. *P < 0.05.
- FIGURE 5.
Mean platelet counts in control dogs, dogs receiving 177Lu-DOTMP, and dogs receiving 153Sm-EDTMP at 37 MBq/kg. Platelet counts did not vary from baseline for dogs receiving 177Lu-DOTMP, but statistically significant differences in means for other groups were present on day 54 (asterisk). Horizontal dashed line represents lower limit of laboratory reference interval at time of 177Lu-DOTMP experiment. *P < 0.05.
- FIGURE 6.
Mean hematocrit in control dogs, dogs receiving 177Lu-DOTMP, and dogs receiving 153Sm-EDTMP at 37 MBq/kg. Hematocrit decreased significantly from baseline for dogs receiving 177Lu-DOTMP only on day 84 and was statistically significantly higher than that in other groups at all other time points (asterisks). Horizontal dashed line represents lower limit of reference interval for laboratory at time of 177Lu-DOTMP experiment. *P < 0.05.
- FIGURE 7.
Changes from baseline for plasma platelet and WBC counts and ALT, ALP, and plasma urea nitrogen (BUN) levels in dogs receiving 177Lu-DOTMP over course of experiment. No change was statistically significant, supporting minimal toxicity and myelosuppression resulting from tested dose of 177Lu-DOTMP.
Tables
Dog Sex Weight (kg) Temperature (°C) Pulse (beats per minute) Respirations (breaths per minute) Physical examination findings Dose administered (MBq) MBq/kg 1 M 27.4 38.4 110 12 Small, benign dermoid, right eye 228.7 8.35 2 M 26.9 38.8 110 12 Bacterial dermatitis, feet and scrotum 240.1 8.93 3 F 27.4 39.5 95 24 Normal 241.2 8.80 4 F 15 38.7 130 16 Normal 130.6 8.71
