Article Figures & Data
Figures
- FIGURE 1.
99mTc-Sestamibi scan of patient with osteitis fibrosa cystica (group III): early (A) and delayed (B) images of right inferior parathyroid adenoma (arrows) weighing 6.5 g before initial surgery.
- FIGURE 2.
99mTc-Sestamibi scan of patient with osteitis fibrosa cystica (group III). (A) Initial image, obtained 5 min after intravenous injection of 99mTc-sestamibi, shows increased uptake in parathyroid gland. (B) Delayed image, obtained at 2 h, shows right inferior parathyroid adenoma weighing 12 g before initial surgery.
- FIGURE 3.
Comparison of 99mTc-sestamibi scans of parathyroid among the 3 clinical groups of PHPT at 5 min (early phase) and 2 h (delayed phase). Accuracy of technique increases in more severely affected patients, approaching 100%. Of patients with severe bone disease (group III), 70% showed increased uptake on early images, in contrast to patients in the other groups, who showed increased uptake only on delayed images.
Tables
- TABLE 1
Clinical Characteristics, Laboratory Values, and BMD Values of the 64 Patients, Stratified by Study Group
Feature Group I (asymptomatic) Group II (renal stone disease) Group III (osteitis fibrosa cystica) P Reference range Age (y) 66.75 ± 0.63 55.8 ± 5.09 38.7 ± 4.38 <0.01 Sex ratio (M:F) 1:4 2:7 11:10 <0.01 Serum calcium (mg/dL) 10.98 ± 0.02 11.32 ± 0.17 13.35 ± 0.35 <0.01 8.6–10.3 Serum phosphorus (mg/dL) 2.79 ± 0.29 2.56 ± 0.47 1.99 ± 0.29 <0.01 2.5–4.5 Serum PTH (pg/mL) 135.45 ± 13.50 165.85 ± 15.06 579.6 ± 628.4 <0.01 10–65 Serum 25-hydroxyvitamin D (ng/mL) 26.97 ± 4.13 20.02 ± 0.56 15.91 ± 1.11 <0.01 12–68 Urine NTx (nmol/mmol of creatinine) 51.3 ± 6.4 154.1 ± 62.9 501.5 ± 201 <0.05 50–60*, 15–120†, 6–65‡ Serum CTx (pg/mL) 752.6 ± 496.3 727.3 ± 220.4 2,210.2 ± 375.4 <0.05 50–450*, 90–680†, 70–480‡ BMD t score Lumbar spine −2.02 ± 0.15 −1.83 ± 0.85 −4.25 ± 0.24 <0.01 Femoral neck −2.03 ± 0.28 −1.81 ± 0.38 −5.44 ± 1.37 <0.01 Distal radius −2.23 ± 0.74 −1.79 ± 0.04 −5.33 ± 0.69 <0.01
