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OtherIMAGING

Comparison of Medium- and High-Energy Collimators for 131I-Tositumomab Dosimetry

Eugene Mah and Ken M. Spicer
Journal of Nuclear Medicine Technology September 2007, 35 (3) 148-153; DOI: https://doi.org/10.2967/jnmt.106.038174
Eugene Mah
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Ken M. Spicer
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  • FIGURE 1. 
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    FIGURE 1. 

    Time–activity curves from whole-body imaging.

  • FIGURE 2. 
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    FIGURE 2. 

    131I decay factors from whole-body measurements. Curves shown are data from Figure 1 normalized to activity at time 0 (A0 in Eq. 2), derived from line-of-best-fit equation.

  • FIGURE 3. 
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    FIGURE 3. 

    Anterior (A) and posterior (B) whole-body images from GE Millennium VG with MEGP collimator.

  • FIGURE 4. 
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    FIGURE 4. 

    Anterior (A) and posterior (B) whole-body images from GE Millennium VG with HEGP collimator.

Tables

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    TABLE 1

    Chest Phantom Activity Distribution

    ChamberVolume (L)Activity concentration (MBq/L)Total activity (MBq)
    Liver1.1756.307.4
    Lungs0.7874.703.7
    Heart (outer chamber)0.11663.87.4
    Thorax8.42.218.5
    • View popup
    TABLE 2

    Abdominal Phantom Activity Distribution

    ChamberVolume (L)Activity concentration (MBq/L)Total activity (MBq)
    Liver1.4756.279.25
    6-cm sphere0.113748.4
    3-cm sphere0.014372.6
    Thorax8.231.1248.7
    • View popup
    TABLE 3

    γ-Camera and Collimator Combinations

    CollimatorGE Millennium VGPhilips Skylight 1Philips Skylight 2Philips Vertex V60
    MEGPXXX
    HEGPXX
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    TABLE 4

    Collimator Specifications

    CollimatorHole diameter (mm)Hole length (mm)Septal thickness (mm)Septal penetration (%)Septal penetration (keV)
    Skylight MEGP2.95481.1433.3300
    Skylight HEGP3.81601.7273.5364
    Vertex V60 MEGP2.95481.1433.3300
    GE Millennium VG MEGP3.0581.05
    GE Millennium VG HEGP4.0661.8
    • View popup
    TABLE 5

    131I Half-Lives Measured from Whole-Body Scans

    Collimator131I half-life, d (% deviation from reference value)
    GE Millennium VG
     MEGP8.135 (1.42)
     HEGP8.042 (0.27)
    Skylight
     MEGP8.175 (1.92)
     HEGP8.194 (2.16)
    Vertex V60 MEGP8.214 (2.41)
    • View popup
    TABLE 6

    131I Half-Lives Measured from Single-Head Acquisitions

    AnteriorPosterior
    Collimator(s)Mean half-life (d)SDDifference* (%)Mean half-life (d)SDDifference* (%)
    All8.130.1321.378.180.1261.93
    MEGP8.200.1232.278.150.0601.58
    HEGP8.020.0040.028.220.2252.46
    • ↵* Between calculated half-life and reference value.

    • View popup
    TABLE 7

    131I-Tositumomab Effective Half-Life, TBRT, and Prescribed Therapeutic Dose for Patient, Calculated with Different γ-Camera and Collimator Combinations

    GE Millennium VGSkylightVertex V60 MEGP
    ParameterMEGPHEGPMEGPHEGP
    Effective half-life (h)79.579.179.679.779.8
    TBRT (h)114.7114.1114.9115.0115.1
    Dose (GBq)2.592.62.592.582.58
    Dose (mCi)7070.469.969.869.8
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Journal of Nuclear Medicine Technology: 35 (3)
Journal of Nuclear Medicine Technology
Vol. 35, Issue 3
September 2007
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Comparison of Medium- and High-Energy Collimators for 131I-Tositumomab Dosimetry
Eugene Mah, Ken M. Spicer
Journal of Nuclear Medicine Technology Sep 2007, 35 (3) 148-153; DOI: 10.2967/jnmt.106.038174

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Comparison of Medium- and High-Energy Collimators for 131I-Tositumomab Dosimetry
Eugene Mah, Ken M. Spicer
Journal of Nuclear Medicine Technology Sep 2007, 35 (3) 148-153; DOI: 10.2967/jnmt.106.038174
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