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OtherIMAGING

Subtraction SPECT for Parathyroid Scintigraphy Based on Maximization of Mutual Information

Narihiro Hara, Teruhiko Takayama, Masahisa Onoguchi, Norikazu Obane, Toshiaki Miyati, Toshiaki Yoshioka, Katsuhiko Sakaguchi and Minoru Honda
Journal of Nuclear Medicine Technology June 2007, 35 (2) 84-90; DOI: https://doi.org/10.2967/jnmt.106.033480
Narihiro Hara
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Teruhiko Takayama
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Masahisa Onoguchi
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Norikazu Obane
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Toshiaki Miyati
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Toshiaki Yoshioka
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Katsuhiko Sakaguchi
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Minoru Honda
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  • FIGURE 1. 
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    FIGURE 1. 

    Appearance (A) and illustration (B) of pair of laser pointers aligned at right angles. Point O corresponds to center of rotation of detectors.

  • FIGURE 2. 
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    FIGURE 2. 

    Planar images used to select reconstructed regions for SPECT images. (A and C) Early planar images. Line marked 63 in A is centerline in 128 matrix. Centerline passes through right and left external auditory canals. Region between lines 13 and 36 is reconstructed region on SPECT images, excluding salivary glands. (B and D) Delayed planar images. Similarly, centerline passes through both external auditory canals. Reconstructed region for delayed SPECT image is similarly selected between lines 13 and 36.

  • FIGURE 3. 
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    FIGURE 3. 

    SPECT images of a patient: early (A), delayed (B), fusion (C), and subtraction (D).

  • FIGURE 4. 
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    FIGURE 4. 

    A 61-y-old man with 4 hyperplastic glands (patient 10). Glands weighed 300–700 mg. In this patient, 24 slices (1–24) were reconstructed. Slice numbers more and less than 24 were considered to represent superior and inferior parathyroid glands, respectively. (A–D) Early planar image (A), delayed planar image (B), and subtraction SPECT images showing upper (C) and lower (D) parathyroid hyperplasia. Arrow indicates hyperplastic lesion.

  • FIGURE 5. 
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    FIGURE 5. 

    A 74-y-old woman with adenoma (patient 12). Lesion weighed 300 mg. (A–C) Early planar image (A), delayed planar image (B), and subtraction SPECT images (C). Lesion (arrow) was seen in left upper region.

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    TABLE 1

    Summary of Clinical Data

    Blood test
    Patient no.Age (y)Calcium (mg/dL) (normal, 8.2–10.2 mg/dL)Phosphorus (mg/dL) (normal, 2.7–4.4 mg/dL)ALP (IU/L) (normal, 115–359 IU/L)Internal secretion, PTH (pg/mL) (normal, 10–60 pg/mL)
    SexDialysisBeforeAfterBeforeAfterBeforeAfterBeforeAfter
    137M+8.87.07.53.9483889101510
    237M+7.16.44.64.335437127460
    354M+9.78.45.83.0403626762140
    460F+9.78.04.63.9298304933136
    562M+8.27.74.53.844383777812
    658M+9.99.87.33.93635844977
    753M+10.27.28.56.21752631,258126
    863M+9.87.87.94.15427487807
    952M+10.08.76.13.427331153312
    1061M+10.07.66.34.32452484905
    1159M+9.48.75.03.94434391,23610
    1274F−10.99.03.63.123323918074
    1364F−11.19.02.72.737032718040
    1456F−11.49.72.92.52872596239
    • ALP = alkaline phosphatase; PTH = parathyroid hormone; before = data within 2 wk before surgery; after = data within 5 d after surgery.

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    TABLE 2

    Results of Scintigraphy, Ultrasonography, and Surgery

    ScintigraphyUltrasonographySurgery/pathology
    Patient no.Location+/−Size (mm)+/−HistopathologyWeight (mg)
    1RU+−Parathyroid hyperplasia350
    RL+16 × 15 × 15+Parathyroid hyperplasia1,650
    LU+−Parathyroid hyperplasia800
    LL+18 × 13 × 11+Parathyroid hyperplasia1,100
    2RU+−Parathyroid hyperplasia1,600
    RL+23 × 10 × 9+Parathyroid hyperplasia200
    LU+−Parathyroid hyperplasia1,300
    LL+6 × 5 × 5+Parathyroid hyperplasia300
    3RU+21 × 14 × 9+Parathyroid hyperplasia1,600
    RL+13 × 11 × 10+Parathyroid hyperplasia500
    LU+−No excision
    LL−12 × 10 × 6+Parathyroid hyperplasia300
    4RU+−Parathyroid hyperplasia500
    RL+10 × 6 × 5+Parathyroid hyperplasia250
    LU+−Parathyroid hyperplasia450
    LL+8 × 8 × 7+Parathyroid hyperplasia400
    5RU−−No excision
    RL−10 × 6 × 5+No excision
    LU+−Parathyroid hyperplasia1,600
    LL+16 × 12 × 10+Parathyroid hyperplasia400
    6RU+−Parathyroid hyperplasia1,450
    RL+11 × 10 × 8+Parathyroid hyperplasia600
    LU+−Parathyroid hyperplasia2,250
    LL+10 × 8 × 7+Parathyroid hyperplasia700
    7RU+6 × 6 × 3+Parathyroid hyperplasia950
    RL+11 × 4 × 3+Parathyroid hyperplasia350
    LU+−Parathyroid hyperplasia2,050
    LL+12 × 11 × 3+Parathyroid hyperplasia350
    8RU+9 × 8 × 8+Parathyroid hyperplasia1,950
    RL+20 × 11 × 14+Parathyroid hyperplasia300
    LU+11 × 7 × 7+Parathyroid hyperplasia250
    LL+11 × 11 × 6+Parathyroid hyperplasia400
    9RU+−Parathyroid hyperplasia1,500
    RL−23 × 13 × 8+Parathyroid hyperplasia900
    LU−−Parathyroid hyperplasia600
    LL−−Parathyroid hyperplasia200
    10RU+10 × 8 × 5+Parathyroid hyperplasia400
    RL+12 × 9 × 7+Parathyroid hyperplasia700
    LU+6 × 6 × 8+Parathyroid hyperplasia300
    LL+10 × 10 × 4+Parathyroid hyperplasia500
    11RU+8 × 7 × 5+Parathyroid hyperplasia100
    RL+13 × 9 × 7+Parathyroid hyperplasia200
    LU+6 × 5 × 4+Parathyroid hyperplasia50
    LL+17 × 13 × 6+Parathyroid hyperplasia500
    12RU−−No excision
    RL−−No excision
    LU+15 × 5 × 3+Adenoma300
    LL+16 × 5 × 3+No excision
    13RU+20 × 7 × 4+Adenoma500
    RL−−No excision
    LU−−No excision
    LL−8 × 8 × 4+No excision
    14RU−−No excision
    RL+6 × 4 × 4+Adenoma300
    LU−−No excision
    LL−−No excision
    • RU = right upper; RL = right lower; LU = left upper; LL = left lower; + = positive; − = negative.

    • View popup
    TABLE 3

    Comparison of Lesion Detection Between Scintigraphy and Ultrasonography

    Ultrasonography(+) (n = 31)Ultrasonography(−) (n = 13)
    Scintigraphy(+/−)LocationRURLLULLRURLLULL
    + (n = 40)RU65
    RL10
    LU46
    LL9
    − (n = 4)RU
    RL1
    LU1
    LL11
    • RU = right upper; RL = right lower; LU = left upper; LL = left lower; + = positive; − = negative.

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Journal of Nuclear Medicine Technology: 35 (2)
Journal of Nuclear Medicine Technology
Vol. 35, Issue 2
June 2007
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Subtraction SPECT for Parathyroid Scintigraphy Based on Maximization of Mutual Information
Narihiro Hara, Teruhiko Takayama, Masahisa Onoguchi, Norikazu Obane, Toshiaki Miyati, Toshiaki Yoshioka, Katsuhiko Sakaguchi, Minoru Honda
Journal of Nuclear Medicine Technology Jun 2007, 35 (2) 84-90; DOI: 10.2967/jnmt.106.033480

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Subtraction SPECT for Parathyroid Scintigraphy Based on Maximization of Mutual Information
Narihiro Hara, Teruhiko Takayama, Masahisa Onoguchi, Norikazu Obane, Toshiaki Miyati, Toshiaki Yoshioka, Katsuhiko Sakaguchi, Minoru Honda
Journal of Nuclear Medicine Technology Jun 2007, 35 (2) 84-90; DOI: 10.2967/jnmt.106.033480
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