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OtherIMAGING

Collimator Selection, Acquisition Speed, and Visual Assessment of 131I-Tositumomab Biodistribution in a Phantom Model

Hung K. Tan, Richard W. Wassenaar and Wanzhen Zeng
Journal of Nuclear Medicine Technology December 2006, 34 (4) 224-227;
Hung K. Tan
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Richard W. Wassenaar
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Wanzhen Zeng
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  • FIGURE 1. 
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    FIGURE 1. 

    Total counts from identical circular regions placed over the 4-cm sphere and over an area of background were used to determine tumor-to-background contrast.

  • FIGURE 2. 
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    FIGURE 2. 

    Anterior and posterior images using high- and medium-energy collimators for acquisition speeds of 20 (A), 60 (B), and 100 (C) cm/min. All images have been adjusted to the same color scale to better illustrate differences in image quality.

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    TABLE 1

    131I Organ Concentrations (MBq/L) Used in Each Experiment (5)

    ExperimentKidneysLungsLiverSpleenHeartBackgroundSphere
    151.138.540.376.21180.148185
    241.123.323.349.28.880.148144
    351.138.540.376.21180.14874
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    TABLE 2

    Half-Life (t1/2) with 95% Confidence Interval (CI) and Tumor-to-Background Contrast Ratios for All Experiments Using Both High-Energy and Medium-Energy Collimators

    Experiment 1Experiment 2Experiment 3
    Acquisition speed (cm/min)Collimator typet1/2 (d)95% CI (d)Contrast ± 1σt1/2 (d)95% CI (d)Contrast ± 1σt1/2 (d)95% CI (d)Contrast ± 1σ
    20High-energy8.38.1, 8.66.6 ± 0.77.97.6, 8.27.5 ± 0.78.47.8, 9.23.9 ± 0.5
    Medium-energy8.58.2, 8.72.5 ± 0.1*7.87.5, 8.13.0 ± 0.1*8.68.0, 9.22.4 ± 0.3*
    100High-energy8.48.0, 8.86.6 ± 0.38.07.7, 8.46.8 ± 0.48.47.6, 9.24.0 ± 0.5
    Medium-energy8.58.2, 8.82.6 ± 0.2*7.97.6, 8.13.0 ± 0.1*8.58.0, 9.02.3 ± 0.2*
    • ↵* P < 0.01, compared with high-energy collimators at same speed.

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Journal of Nuclear Medicine Technology: 34 (4)
Journal of Nuclear Medicine Technology
Vol. 34, Issue 4
December 2006
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Collimator Selection, Acquisition Speed, and Visual Assessment of 131I-Tositumomab Biodistribution in a Phantom Model
Hung K. Tan, Richard W. Wassenaar, Wanzhen Zeng
Journal of Nuclear Medicine Technology Dec 2006, 34 (4) 224-227;

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Collimator Selection, Acquisition Speed, and Visual Assessment of 131I-Tositumomab Biodistribution in a Phantom Model
Hung K. Tan, Richard W. Wassenaar, Wanzhen Zeng
Journal of Nuclear Medicine Technology Dec 2006, 34 (4) 224-227;
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