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OtherIMAGING

Administered Activity Optimization in 99mTc-MAG3 Renography for Adults

Marlén P. Díaz, Eric E. Aparicio, Oscar D. Rizo, Reinaldo R. Díaz and Carlos H. Rodríguez
Journal of Nuclear Medicine Technology December 2003, 31 (4) 216-221;
Marlén P. Díaz
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Eric E. Aparicio
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Oscar D. Rizo
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Reinaldo R. Díaz
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Carlos H. Rodríguez
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  • FIGURE 1.
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    FIGURE 1.

    Images obtained with 45 MBq (A), 71 MBq (B), or 132 MBq (C) of 99mTc-MAG3 and their corresponding renograms for both whole kidneys.

Tables

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    • View popup
    TABLE 1

    Patient Characteristics

    Patient no.Age (y)SexWeight (kg)
    145F76
    246M68
    352F54
    429F58
    518F43
    649M123
    774M116
    818M49
    950F70
    1043F66
    Mean ± SD42.4 ± 16.973.5 ± 26.8
    1135F73
    1220F57
    1340F61
    1435M78
    1544F59
    1642M67
    1751F85
    1829F54
    1952F61
    2055F67
    Mean ± SD40.3 ± 10.966.2 ± 9.8
    2119M83
    2231F66
    2368M55
    2455M81
    2537F41
    2638F50
    2718F64
    2846F44
    2965F54
    3038F64
    Mean ± SD41.5 ± 17.260.2 ± 14.2
    • View popup
    TABLE 2

    Measured Variables

    Patient no.TMLK (min)TMRK (min)Counting rate (cps)LY (%)LK/BRK/BLC/BRC/BA2LK (%)A2RK (%)ERPF (%)
    LeftRightLeftRight
    12.72.0248248904.64.03.82.511.813.54654
    22.33.1186284904.25.22.94.111.016.74258
    33.51.532599903.01.02.40.521.16.43928
    410.530232285872.73.52.73.014.117.17220
    53.72.6326459874.03.53.33.023.028.04357
    62.63.715788873.44.23.03.211.45.92928
    72418166226913.92.03.71.69.5814.13961
    8—7.527222991—3.0—2.4—19.3—98
    92.22.5170215915.44.34.43.813.114.24852
    103.83.6161223904.74.64.34.213.113.65149
    112.7—262—906.8—5.219.9—96—
    12305.6243131916.81.86.21.525.827.33664
    132.1—164—913.3—2.9—13.6—94—
    146.3—216—9111.1—9.2—18.7—93—
    1521.613.9106200873.22.82.72.17.515.22971
    1618.717.210781901.72.31.42.06.615.81585
    172.73.486216901.91.81.81.38.66.45842
    182.83.724170903.60.73.40.419.055.38515
    19—5.61139490—2.5—1.9—11.2—99
    2017.63.7221206907.03.16.52.713.217.45347
    211.91.845193900.73.30.73.37.647.41987
    223.23.4151201884.64.24.14.217.823.62377
    232.82.836206880.32.90.22.84.525.2793
    242.81.8136137885.22.24.62.017.116.94852
    252.510.526894906.91.96.61.628.29.99010
    263.07.523965907.70.66.80.525.16.79010
    271.91.9213210904.33.24.12.520.020.05149
    282.22.7179130904.11.43.50.922.616.96040
    2920.25.227142900.92.50.92.218.99.21684
    302.93.7130108903.21.82.91.616.715.16040
    • LY = labeling yield.

    • Patients 8, 11, 13, 14, and 19 had only 1 kidney. Counting rate is at 2 min after injection.

    • View popup
    TABLE 3

    Clusters with Differentiated Image Quality

    VariablesValue in clusterPatient classification in cluster
    1212
    LK/B3.834.01
    LC/B3.233.62
    RK/B2.423.393, 6, 12, 17, 18, 19,1, 2, 4, 5, 7, 8, 9,
    RC/B2.062.7524, 25, 26, 28, 29,10, 15, 16, 20, 21,
    A2LK (%)15183022, 23, 27
    A2RK (%)1618
    Labeling yield (%)9092.3
    • The software could not classify patients 11, 13, and 14.

    • View popup
    TABLE 4

    Importance of Variables for Image Quality

    Rank from highest to lowest importanceCorrelation coefficient with discriminant function
    RK/B0.646
    RC/B0.467
    A2RK0.290
    A2LK0.162
    Labeling yield0.137
    LK/B0.035
    LC/B0.029
    • View popup
    TABLE 5

    Absorbed and Effective Doses in Some Organs After Different Administered Activities of 99mTc-MAG3

    OrganAdministered activity
    185 MBq (common value)100 MBq (IAEA value)45 mBq (optimized value)
    Absorbed dose (mGy)
     Red marrow3.301.800.80
     Kidneys33.3018.008.10
     Bladder32.3717.507.87
     Liver9.255.202.20
     Ovaries2.221.200.54
     Testes1.110.600.27
     Whole body1.100.590.26
    Effective dose (mSv)4.862.641.17
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Journal of Nuclear Medicine Technology: 31 (4)
Journal of Nuclear Medicine Technology
Vol. 31, Issue 4
December 1, 2003
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Administered Activity Optimization in 99mTc-MAG3 Renography for Adults
Marlén P. Díaz, Eric E. Aparicio, Oscar D. Rizo, Reinaldo R. Díaz, Carlos H. Rodríguez
Journal of Nuclear Medicine Technology Dec 2003, 31 (4) 216-221;

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Administered Activity Optimization in 99mTc-MAG3 Renography for Adults
Marlén P. Díaz, Eric E. Aparicio, Oscar D. Rizo, Reinaldo R. Díaz, Carlos H. Rodríguez
Journal of Nuclear Medicine Technology Dec 2003, 31 (4) 216-221;
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