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Journal of Nuclear Medicine Technology

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OtherCONTINUING EDUCATION

Nonosseous Abnormalities on Bone Scans*

Issa Loutfi, B. David Collier and Ahmed M. Mohammed
Journal of Nuclear Medicine Technology September 2003, 31 (3) 149-153;
Issa Loutfi
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B. David Collier
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Ahmed M. Mohammed
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  • FIGURE 1.
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    FIGURE 1.

    Injection of 99mTc-MDP into radial artery of right hand produces dramatic soft-tissue uptake in arterial distribution along lateral side of hand and wrist (anterior view). SK = skull; PEL ABD = pelvis and abdomen.

  • FIGURE 2.
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    FIGURE 2.

    Blood-pool image of posterior lower back shows blunting of lower pole of right kidney and uptake in soft-tissue mass (arrow), which proved to be renal cell carcinoma.

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    FIGURE 3.

    Grossly dilated left ureter and renal collecting system seen on anterior whole-body 99mTc-MDP bone scan of patient with prostate cancer. Indwelling Foley catheter was in place at time of scanning.

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    FIGURE 4.

    Anterior (right) and posterior (left) abdominal views of 99mTc-MDP bone scan of patient with hepatic metastasis from colon carcinoma show intense uptake of radioactivity in liver, which is heavily involved with tumor.

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    FIGURE 5.

    Left anterior oblique (right) and right anterior oblique (left) views of chest from 99mTc-MDP bone scan of patient with left-breast cancer show soft-tissue uptake in both breasts. Uptake in left breast is more extensive (arrow) and corresponds to tumor mass on that side.

  • FIGURE 6.
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    FIGURE 6.

    (A) Planar posterior image of lower back from 99mTc-MDP bone scan of patient with chronic back pain. Focus of increased uptake is seen in region of left pedicle of 3rd lumbar vertebra (arrow). (B) SPECT image shows this uptake to be more superficial in overlying soft tissue (arrow). Patient had received injections of antiinflammatory drugs at this site a few weeks before scan.

Tables

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    TABLE 1

    Effects of Faulty Radiopharmaceutical Preparation on Bone Scan

    FaultEffect on bone scan
    Free pertechnetate due to presence of air in container, a long-standing preparation, an inappropriate amount of stannous ion, or altered preparationThyroid uptake on early images (blood pool) and stomach, gastrointestinal tract, and salivary gland uptake
    Colloid formation due to aluminumDiffuse liver uptake and reduced bone uptake
    High pH in the preparationLiver, gallbladder, and gastrointestinal tract uptake
    Drug interaction:
        Diphosphonates, etidronateDecreased bone uptake
        IronIncreased soft-tissue uptake; renal cortex uptake
        ChemotherapyRenal cortex uptake and diffuse skull uptake
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    TABLE 2

    Soft-Tissue Uptake That Often Is Clinically Significant

    Organ or tissuePathologic condition
    BreastBreast cancer
    Pleural spaceMalignant effusion
    LiverCalcified or necrotic metastases
    HeartAmyloidosis or infarction
    SpleenSickle cell disease
    BrainInfarction
    MuscleHeterotopic ossification or myositis
    StomachHypercalcemia, metastatic calcification
    LungHypercalcemia, metastatic calcification
    Renal cortexHypercalcemia
    JointsOsteochondromatosis
    PericardiumPericarditis or malignant effusion
    Soft-tissue tumorOsteogenic sarcoma or malignancy
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Journal of Nuclear Medicine Technology: 31 (3)
Journal of Nuclear Medicine Technology
Vol. 31, Issue 3
September 1, 2003
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Nonosseous Abnormalities on Bone Scans*
Issa Loutfi, B. David Collier, Ahmed M. Mohammed
Journal of Nuclear Medicine Technology Sep 2003, 31 (3) 149-153;

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Nonosseous Abnormalities on Bone Scans*
Issa Loutfi, B. David Collier, Ahmed M. Mohammed
Journal of Nuclear Medicine Technology Sep 2003, 31 (3) 149-153;
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  • Article
    • Abstract
    • TECHNICAL ARTIFACTS
    • NONOSSEOUS FINDINGS RELATED TO URINARY SYSTEM
    • SOFT-TISSUE FINDINGS ON BONE SCANS
    • CONCLUSION
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