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Journal of Nuclear Medicine Technology

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OtherRADIOPHARMACY

Dextrose Solutions Yield Radiochemical Impurities: The “Sweet” Scans

Eman Al-Enizi, Nafisah Kazem, Azu Owunwanne, B. David Collier and Mercy Mathew
Journal of Nuclear Medicine Technology March 2003, 31 (1) 33-36;
Eman Al-Enizi
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Nafisah Kazem
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Azu Owunwanne
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B. David Collier
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Mercy Mathew
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  • FIGURE 1.
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    FIGURE 1.

    Anterior-view 99mTc-stannous colloid image shows unexpected findings of significant kidney, bladder, cardiac blood- pool, and soft-tissue background activity indicating altered biodistribution as well as uptake in liver and spleen.

  • FIGURE 2.
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    FIGURE 2.

    Whole-body anterior- and posterior-view 99mTc-MDP images show unexpected findings of significant kidney, bladder, cardiac blood-pool, gallbladder, and soft-tissue background activity.

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    FIGURE 3.

    Series of 4 anterior-view images over first 10 min after injection of 99mTc-mebrofenin in patient with normal liver function. Images show reduced liver uptake with no excretion into bile ducts and significant kidney, cardiac blood-pool, and soft-tissue background activity.

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    FIGURE 4.

    Saline chromatograms of 99mTc-MDP preparations for which 99mTc-pertechnetate was diluted with either normal saline (A) or 5% dextrose (B). Notice that preparation B contains radiopharmaceutical impurities that do not migrate with solvent front.

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    TABLE 1.

    Results of Thin-Layer Chromatography

    Radiopharmaceutical (prepared with either dextrose or saline)% Activity toward origin% Activity toward solvent frontSolvent
    MDP (saline)595Saline
    MDP (dextrose)4753Saline
    Tin colloid (saline)955Acetone
    Tin colloid (dextrose)8515Acetone
    Mebrofenin (saline)982Water
    Mebrofenin (dextrose)964Water
    Tetrofosmin (saline)982Ethyl alcohol
    Tetrofosmin (dextrose)982Ethyl alcohol
    • MDP = methylene diphosphonate.

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Journal of Nuclear Medicine Technology: 31 (1)
Journal of Nuclear Medicine Technology
Vol. 31, Issue 1
March 1, 2003
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Dextrose Solutions Yield Radiochemical Impurities: The “Sweet” Scans
Eman Al-Enizi, Nafisah Kazem, Azu Owunwanne, B. David Collier, Mercy Mathew
Journal of Nuclear Medicine Technology Mar 2003, 31 (1) 33-36;

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Dextrose Solutions Yield Radiochemical Impurities: The “Sweet” Scans
Eman Al-Enizi, Nafisah Kazem, Azu Owunwanne, B. David Collier, Mercy Mathew
Journal of Nuclear Medicine Technology Mar 2003, 31 (1) 33-36;
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