@article {Al-Enizi33, author = {Eman Al-Enizi and Nafisah Kazem and Azu Owunwanne and B. David Collier and Mercy Mathew}, title = {Dextrose Solutions Yield Radiochemical Impurities: The {\textquotedblleft}Sweet{\textquotedblright} Scans}, volume = {31}, number = {1}, pages = {33--36}, year = {2003}, publisher = {Society of Nuclear Medicine}, abstract = {Objective:If additional chemicals are inadvertently introduced in the preparation of radiopharmaceutical kits, radiochemical impurities may be formed. We report our experience with erroneously diluting 99mTc-pertechnetate eluate with 5\% dextrose solution rather than normal saline during the preparation of 99mTc-tetrofosmin, 99mTc-methylene diphosphonate (MDP), 99mTc-stannous colloid, and 99mTc-mebrofenin. Methods:Scintigrams for 3 of the 4 radiochemicals unintentionally prepared with 5\% dextrose were found to have an altered biodistribution. Therefore, radiopharmacy procedures for the day were reviewed, and instant thin-layer chromatography (ITLC) was performed. Results:Scintigrams showed an altered biodistribution consistent with an impurity. Review of procedures that day uncovered the error of using 5\% dextrose to dilute the 99mTc eluate. The altered biodistribution on 99mTc-stannous colloid, 99mTc-MDP, and 99mTc-mebrofenin scintigrams consisted of cardiac blood-pool activity (possibly as a result of slow clearance of 99mTc-dextrose), soft-tissue background activity (possibly as a result of interstitial distribution of 99mTc-dextrose), renal and bladder activity (possibly as a result of renal elimination of 99mTc-dextrose), and gallbladder activity (possibly as a result of hepatobiliary excretion of 99mTc-dextrose). Both scintigrams and ITLC showed no evidence of impurities for the 99mTc-tetrofosmin prepared using 5\% dextrose. Conclusion:Unintended preparation of radiochemicals with 5\% dextrose rather than normal saline often results in the production of impurities, possibly 99mTc-dextrose. Because some but not all commercial radiochemical kits prepared with 5\% dextrose will suffer this fate, nuclear medicine physicians reviewing the day{\textquoteright}s images will be confronted with a confusing combination of expected and grossly abnormal findings.}, issn = {0091-4916}, URL = {https://tech.snmjournals.org/content/31/1/33}, eprint = {https://tech.snmjournals.org/content/31/1/33.full.pdf}, journal = {Journal of Nuclear Medicine Technology} }