Minimum Detectable Defect Thickness in SPECT Myocardial Perfusion Test: Phantom Study with 99mTc and 201Tl

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FIGURE 1.
Locations of defects inside myocardial phantom. D = thickness (depth) of the defect.
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FIGURE 2.
Example of short-axis, vertical long-axis, and horizontal long-axis slices showing nonuniformity of baseline SPECT images.
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FIGURE 3.
Phantom SPECT images for ROR = 29.2 cm, with ^99mTc (row A) and ²⁰¹Tl (row B) where 5 defects with thickness D = 6 mm were inserted. All defects are clearly detected with both tracers except defect located in SEP region in ²⁰¹Tl study.
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FIGURE 4.
Phantom SPECT images with ^99mTc (row A) and ²⁰¹Tl (row B) at ROR = 25.0 cm. Four defects of 22.5 × 22.5 × 4 mm³ (∼ 2 mL) were fixed at ANT, SEP, IP, and LAT regions. All defects were detected with ^99mTc; only the defect located in IP region was detected with ²⁰¹Tl.
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FIGURE 5.
Phantom SPECT images for ROR = 25.0 cm with ^99mTc (row A). Two 1-mL defects were inserted into ANT, SEP, IP, and LAT regions. All 6-mm defects are clearly seen; 3-mm defects are visible in IP region only.

TABLE 2

Minimum Detectable Defect Thickness for ^99mTc and ²⁰¹Tl

Isotope	ROR (cm)	D_min (mm; percentage of myocardial phantom wall thickness)
Isotope	ROR (cm)	ANT	SEP	IP	LAT	AP
^99mTc	21.0	4 (33%)	4 (33%)	2 (16%)	4 (33%)	3 (25%)
	25.0	4 (33%)	4 (33%)	2 (16%)	4 (33%)	4 (33%)
	29.2	4 (33%)	5 (43%)	3 (25%)	4 (33%)	4 (33%)
²⁰¹Tl	21.0	6 (50%)	6 (50%)	3 (25%)	5 (43%)	4 (33%)
	25.0	6 (50%)	6 (50%)	3 (25%)	6 (50%)	4 (33%)
	29.2	6 (50%)	7 (58%)	4 (33%)	6 (50%)	4 (33%)