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Journal of Nuclear Medicine Technology

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Nuclear Pharmacy

Rapid Quality Control of Technetium-99m-2-Methoxy Isobutyl Isonitrile (Technetium-99m-Sestamibi)

Jerry I. Hirsch and Mark W. Watson
Journal of Nuclear Medicine Technology June 1996, 24 (2) 114-118;
Jerry I. Hirsch
Nuclear Medicine Division, Virginia Commonwealth University/Medical College of Virginia, Richmond, Virginia and DuPont Merck Pharmaceutical Co., North Billerica, Massachusetts
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Mark W. Watson
Nuclear Medicine Division, Virginia Commonwealth University/Medical College of Virginia, Richmond, Virginia and DuPont Merck Pharmaceutical Co., North Billerica, Massachusetts
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Abstract

Objective: Technetium-99m-sestamibi (99mTc-MIBI) is a radiopharmaceutical imaging agent useful for assessing myocardial perfusion. We present a simple, rapid and accurate SepPak® method to confirm the radiochemical purity of 99mTc-MIBI.

Methods: Technetium-99m-MIBI preparations of high (>95%), intermediate (83–90%) and low (25–43%) radiochemical purity were evaluated by the recommended thinlayer chromatography (TLC) procedure. Radiochemical purities were simultaneously determined by Alumina-N and C-18 SepPak treatment using 95% ethanol and 0.9% sodium chloride injection, USP as eluents. Statistical analysis was used to determine concordance between TLC and corresponding SepPak values for the entire range of 99mTc-MIBI purity studied.

Results: For all purity groups studied, a significant difference was found when 99mTc-MIBI radiochemical purity values by the C-18 SepPak method were compared to values obtained by the recommended TLC procedure. However, no statistical difference in 99mTc-MIBI radiochemical purity values were found when Alumina-N SepPaks, treated with sufficient eluent, were compared to values obtained by the recommended TLC procedure.

Conclusion: This study demonstrates that an Alumina-N SepPak method can be routinely used as an alternative to the recommended TLC method for the radiochemical purity determination of 99mTc-MIBI.

  • technetium-99m-sestamibi
  • radiochemical purity
  • quality control
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Journal of Nuclear Medicine Technology: 24 (2)
Journal of Nuclear Medicine Technology
Vol. 24, Issue 2
June 1, 1996
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Rapid Quality Control of Technetium-99m-2-Methoxy Isobutyl Isonitrile (Technetium-99m-Sestamibi)
Jerry I. Hirsch, Mark W. Watson
Journal of Nuclear Medicine Technology Jun 1996, 24 (2) 114-118;

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Rapid Quality Control of Technetium-99m-2-Methoxy Isobutyl Isonitrile (Technetium-99m-Sestamibi)
Jerry I. Hirsch, Mark W. Watson
Journal of Nuclear Medicine Technology Jun 1996, 24 (2) 114-118;
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Keywords

  • technetium-99m-sestamibi
  • radiochemical purity
  • quality control
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