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Radiopharmacy

Indium-111 Platelet Labeling Using Homologous Platelets

Charles Colloms, Kenneth T. Cheng and Dave Haymond
Journal of Nuclear Medicine Technology December 1994, 22 (4) 222-224;
Charles Colloms
Nuclear Pharmacy, Medical University of South Carolina, Charleston, South Carolina
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Kenneth T. Cheng
Nuclear Pharmacy, Medical University of South Carolina, Charleston, South Carolina
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Dave Haymond
Nuclear Pharmacy, Medical University of South Carolina, Charleston, South Carolina
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Abstract

Objective: This paper describes an 111In-labeled platelet procedure using substituted donor platelets (homologous) in acutely thrombocytopenic patients.

Methods: In two patients, we used packed donor platelets which were centrifuged once. Once the platelets were isolated, they were incubated with 111In-oxine in an anticoagulated solution of normal saline for 5 min. Upon resuspension in the plasma, the platelets were injected into the patients who were imaged with a dual-headed SPECT camera the following day.

Results: We successfully labeled packed donor platelets to produce clinically acceptable images by modifying the current standard protocol for platelet labeling.

Conclusion: Indium-111 platelet labeling of donor platelets is a feasible alternative to autologous labeling in acutely thrombocytopenic patients.

  • platelet labeling
  • indium-111-oxine
  • thrombocytopenic patients
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Journal of Nuclear Medicine Technology: 22 (4)
Journal of Nuclear Medicine Technology
Vol. 22, Issue 4
December 1, 1994
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Indium-111 Platelet Labeling Using Homologous Platelets
Charles Colloms, Kenneth T. Cheng, Dave Haymond
Journal of Nuclear Medicine Technology Dec 1994, 22 (4) 222-224;

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Indium-111 Platelet Labeling Using Homologous Platelets
Charles Colloms, Kenneth T. Cheng, Dave Haymond
Journal of Nuclear Medicine Technology Dec 1994, 22 (4) 222-224;
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Keywords

  • platelet labeling
  • indium-111-oxine
  • thrombocytopenic patients
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