Indium-111 Platelet Labeling Using Homologous Platelets

Abstract

Objective: This paper describes an ¹¹¹In-labeled platelet procedure using substituted donor platelets (homologous) in acutely thrombocytopenic patients.

Methods: In two patients, we used packed donor platelets which were centrifuged once. Once the platelets were isolated, they were incubated with ¹¹¹In-oxine in an anticoagulated solution of normal saline for 5 min. Upon resuspension in the plasma, the platelets were injected into the patients who were imaged with a dual-headed SPECT camera the following day.

Results: We successfully labeled packed donor platelets to produce clinically acceptable images by modifying the current standard protocol for platelet labeling.

Conclusion: Indium-111 platelet labeling of donor platelets is a feasible alternative to autologous labeling in acutely thrombocytopenic patients.