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Journal of Nuclear Medicine Technology

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Radiopharmacy

Use of a Single-Strip Chromatography System to Assess the Lipophilic Component in Technetium-99m Exametazime Preparations

Denise I. Webber, A. Michael Zimmer, Monica C. Geyer and Stewart M. Spies
Journal of Nuclear Medicine Technology March 1992, 20 (1) 29-32;
Denise I. Webber
Northwestern University Medical Center, Chicago, Illinois
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A. Michael Zimmer
Northwestern University Medical Center, Chicago, Illinois
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Monica C. Geyer
Northwestern University Medical Center, Chicago, Illinois
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Stewart M. Spies
Northwestern University Medical Center, Chicago, Illinois
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Abstract

Use of a single-strip miniaturized chromatography system to quantitate the lipophilic component in technetium-99m (99mTc) exametazime preparations was investigated. The chromatography system consisted of Whatman 17 strips and ethyl acetate as the solvent system. The operation parameters, accuracy and reliability of the single-strip chromatography system, were evaluated. Results of the study demonstrated that the single-strip chromatography system was accurate in assessing the lipophilic fraction in 99mTc exametazime preparations when compared to the three-strip chromatography method. The single strip system is rapid with a solvent developing time of ~2 min. As outlined, the single-strip chromatography system can easily be incorporated into the radiopharmaceutical quality control program of any nuclear medicine department.

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Journal of Nuclear Medicine Technology: 20 (1)
Journal of Nuclear Medicine Technology
Vol. 20, Issue 1
March 1, 1992
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Use of a Single-Strip Chromatography System to Assess the Lipophilic Component in Technetium-99m Exametazime Preparations
Denise I. Webber, A. Michael Zimmer, Monica C. Geyer, Stewart M. Spies
Journal of Nuclear Medicine Technology Mar 1992, 20 (1) 29-32;

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Use of a Single-Strip Chromatography System to Assess the Lipophilic Component in Technetium-99m Exametazime Preparations
Denise I. Webber, A. Michael Zimmer, Monica C. Geyer, Stewart M. Spies
Journal of Nuclear Medicine Technology Mar 1992, 20 (1) 29-32;
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