RT Journal Article
SR Electronic
T1 Use of a Single-Strip Chromatography System to Assess the Lipophilic Component in Technetium-99m Exametazime Preparations
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 29
OP 32
VO 20
IS 1
A1 Webber, Denise I.
A1 Zimmer, A. Michael
A1 Geyer, Monica C.
A1 Spies, Stewart M.
YR 1992
UL http://tech.snmjournals.org/content/20/1/29.abstract
AB Use of a single-strip miniaturized chromatography system to quantitate the lipophilic component in technetium-99m (99mTc) exametazime preparations was investigated. The chromatography system consisted of Whatman 17 strips and ethyl acetate as the solvent system. The operation parameters, accuracy and reliability of the single-strip chromatography system, were evaluated. Results of the study demonstrated that the single-strip chromatography system was accurate in assessing the lipophilic fraction in 99mTc exametazime preparations when compared to the three-strip chromatography method. The single strip system is rapid with a solvent developing time of ~2 min. As outlined, the single-strip chromatography system can easily be incorporated into the radiopharmaceutical quality control program of any nuclear medicine department.