Dual-Isotope Protocol for Indium-111 Capromab Pendetide Monoclonal Antibody Imaging

Abstract

Objective: A dual-isotope imaging protocol using ^99mTc-labeled red blood cells with ¹¹¹In capromab pendetide monoclonal antibody imaging for detecting and localizing nodal metastasis in prostate cancer is described.

Methods: This protocol involves a single SPECT acquisition that is less time consuming and more comfortable for the patient than the currently recommended method, which requires two separate SPECT acquisitions performed on different days.

Results: Forty patients were studied with the dual-isotope protocol. Preliminary data suggest increased accuracy compared with the single-isotope technique.

Conclusion: The dual-isotope technique assures the precise image registration needed for accurate comparison of blood pool and pelvic lymph node activity that is required for confident and accurate image interpretation.