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Research ArticleImaging

Imaging Pathway of a Pediatric Patient with Succinate Dehydrogenase B-Deficient Paraganglioma

Stephen Edmonds, Jennifer Davidson, Rosanne Joseph and Madhusudan Vyas
Journal of Nuclear Medicine Technology September 2023, jnmt.123.265655; DOI: https://doi.org/10.2967/jnmt.123.265655
Stephen Edmonds
1Mercy Radiology, Auckland, New Zealand;
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Jennifer Davidson
1Mercy Radiology, Auckland, New Zealand;
2Auckland Hospital, Auckland, New Zealand; and
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Rosanne Joseph
1Mercy Radiology, Auckland, New Zealand;
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Madhusudan Vyas
1Mercy Radiology, Auckland, New Zealand;
3Unitec Institute of Technology, Auckland, New Zealand
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    FIGURE 1.

    Diagnostic imaging and treatment pathway. Although not to scale, x-axis demonstrates first indication of abnormality at 2,246 d from initial general practitioner referral for back pain. CR = complete remission; DX = diagnostic; GP = general practitioner; NM = nuclear medicine.

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    FIGURE 2.

    Coronal sagittal and axial whole-body 123I-MIBG/CT imaging of adrenal 1 mo before first 177Lu therapy.

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    FIGURE 3.

    Coronal, sagittal, and axial whole-body 68Ga-DOTATATE/CT imaging showing lesion in thoracic spine (a), lesion in pelvic region (b), and normal tissue (c).

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    FIGURE 4.

    Whole-body 123I-MIBG of adrenal illustrating thoracic and pelvic masses before 177Lu-DOTATATE therapy and 19 h after 123I-MIBG injection (left) and after fourth 177Lu-DOTATATE therapy scan and 23 h after 177Lu (right). Pelvis mass has SUV of 50.9, and left intrathoracic mass has SUV of 11.8. 177Lu dose was 7,593 MBq for fourth therapy, and cumulative dose was 3,090 MBq. RT = right.

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Journal of Nuclear Medicine Technology: 53 (1)
Journal of Nuclear Medicine Technology
Vol. 53, Issue 1
March 1, 2025
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Imaging Pathway of a Pediatric Patient with Succinate Dehydrogenase B-Deficient Paraganglioma
Stephen Edmonds, Jennifer Davidson, Rosanne Joseph, Madhusudan Vyas
Journal of Nuclear Medicine Technology Sep 2023, jnmt.123.265655; DOI: 10.2967/jnmt.123.265655

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Imaging Pathway of a Pediatric Patient with Succinate Dehydrogenase B-Deficient Paraganglioma
Stephen Edmonds, Jennifer Davidson, Rosanne Joseph, Madhusudan Vyas
Journal of Nuclear Medicine Technology Sep 2023, jnmt.123.265655; DOI: 10.2967/jnmt.123.265655
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Keywords

  • Neuroendocrine
  • gallium-68-DOTATATE
  • molecular biology
  • paraganglioma
  • Peptide Receptor Radionuclide Therapy
  • PRRT
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