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Research ArticleBrief Communication

Novel Tracers for the Imaging of Cardiac Amyloidosis

Mrinali Shetty and Saurabh Malhotra
Journal of Nuclear Medicine Technology May 2023, 265568; DOI: https://doi.org/10.2967/jnmt.123.265568
Mrinali Shetty
1Columbia University Irving Medical Center, New York, New York; and
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Saurabh Malhotra
2Rush Medical College, Chicago, Illinois
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Abstract

Radionuclide scintigraphy with technetium-labeled bisphosphonates has brought a paradigm shift in diagnosing cardiac amyloidosis (CA), with transthyretin CA now being effectively diagnosed without the need for tissue biopsy. Yet, deficits remain, such as methods for the noninvasive diagnosis of light-chain CA, means to detect CA early, prognostication, monitoring, and therapy response assessment. To address these issues, there has been growing interest in the development and implementation of amyloid-specific radiotracers for PET. The aim of this review is to educate the reader on these novel imaging tracers. Though still investigational, these novel tracers—given their many advantages—are clearly the future of nuclear imaging in CA.

  • cardiac amyloidosis
  • radiotracers
  • PET
  • PYP
  • HFpEF
  • cardiomyopathy

Footnotes

  • Published online May 16, 2023.

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Journal of Nuclear Medicine Technology: 51 (3)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 3
September 1, 2023
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Novel Tracers for the Imaging of Cardiac Amyloidosis
Mrinali Shetty, Saurabh Malhotra
Journal of Nuclear Medicine Technology May 2023, 265568; DOI: 10.2967/jnmt.123.265568

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Novel Tracers for the Imaging of Cardiac Amyloidosis
Mrinali Shetty, Saurabh Malhotra
Journal of Nuclear Medicine Technology May 2023, 265568; DOI: 10.2967/jnmt.123.265568
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  • Article
    • Abstract
    • NON–AMYLOID-SPECIFIC PROBES
    • AMYLOID-SPECIFIC PROBES
    • SUMMARY
    • DISCLOSURE
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More in this TOC Section

  • Alternative Isotope Options for Amyloidosis Imaging: A Technologist’s Perspective
  • Peptide Receptor Radionuclide Therapy in Merkel Cell Carcinoma: A Comprehensive Review
Show more Brief Communication

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Keywords

  • cardiac amyloidosis
  • radiotracers
  • PET
  • PYP
  • HFpEF
  • cardiomyopathy
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