RT Journal Article
SR Electronic
T1 Novel Tracers for the Imaging of Cardiac Amyloidosis
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 265568
DO 10.2967/jnmt.123.265568
A1 Mrinali Shetty
A1 Saurabh Malhotra
YR 2023
UL http://tech.snmjournals.org/content/early/2023/05/16/jnmt.123.265568.abstract
AB Radionuclide scintigraphy with technetium-labeled bisphosphonates has brought a paradigm shift in diagnosing cardiac amyloidosis (CA), with transthyretin CA now being effectively diagnosed without the need for tissue biopsy. Yet, deficits remain, such as methods for the noninvasive diagnosis of light-chain CA, means to detect CA early, prognostication, monitoring, and therapy response assessment. To address these issues, there has been growing interest in the development and implementation of amyloid-specific radiotracers for PET. The aim of this review is to educate the reader on these novel imaging tracers. Though still investigational, these novel tracers—given their many advantages—are clearly the future of nuclear imaging in CA.