PT  - JOURNAL ARTICLE
AU  - Mrinali Shetty
AU  - Saurabh Malhotra
TI  - Novel Tracers for the Imaging of Cardiac Amyloidosis
AID  - 10.2967/jnmt.123.265568
DP  - 2023 May 16
TA  - Journal of Nuclear Medicine Technology
PG  - 265568
4099  - http://tech.snmjournals.org/content/early/2023/05/16/jnmt.123.265568.short
4100  - http://tech.snmjournals.org/content/early/2023/05/16/jnmt.123.265568.full
AB  - Radionuclide scintigraphy with technetium-labeled bisphosphonates has brought a paradigm shift in diagnosing cardiac amyloidosis (CA), with transthyretin CA now being effectively diagnosed without the need for tissue biopsy. Yet, deficits remain, such as methods for the noninvasive diagnosis of light-chain CA, means to detect CA early, prognostication, monitoring, and therapy response assessment. To address these issues, there has been growing interest in the development and implementation of amyloid-specific radiotracers for PET. The aim of this review is to educate the reader on these novel imaging tracers. Though still investigational, these novel tracers—given their many advantages—are clearly the future of nuclear imaging in CA.