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OtherTeaching Case Studies

Poorly differentiated Neuroendocrine carcinoma (small cell) of Parotid Gland and ‘Moderately differentiated’ Hepatic metastases: a Discordant Histopathology clarified by dual tracer PET-CT (68Ga-DOTATATE and 18F-FDG) for predicting tumor biology and treatment decision-making

Priyanka Sharma and Sandip Basu
Journal of Nuclear Medicine Technology October 2020, jnmt.120.251587; DOI: https://doi.org/10.2967/jnmt.120.251587
Priyanka Sharma
Radiation Medicine Centre, Bhabha Atomic Research Centre, India
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Sandip Basu
Radiation Medicine Centre, Bhabha Atomic Research Centre, India
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Abstract

Metastatic neuroendocrine neoplasms (NEN) of the parotid gland, with discordant histopathology reports between primary parotid tumor (poorly differentiated small cell neuroendocrine carcinoma) and large hepatic metastasis (atypical carcinoid with moderately differentiation status, Ki-67 15-20%), and the value of dual tracer PET-CT imaging (68Ga-DOTATATE and 18F-FDG) features in such clinical setting are illustrated. Minimal 68Ga-DOTATATE and high grade 18FDG uptake of the lesions indicated a poor differentiation status helped in clarifying tumor biology, with its potential implications for subsequent treatment-decision individualization in favor of chemotherapy. The findings underscore the clinical utility of dual tracer PET-CT in appropriating the assessment in patients/situations with conflicting or discordant histopathology at two sites in an individual.

  • Neuroendocrine
  • Oncology: Endocrine
  • Oncology: Head and neck
  • PET/CT
  • FDG PET-CT
  • Neuroendocrine Tumour (NET)
  • Neuroendocrine neoplasm (NEN)
  • Parotid Gland
  • [68Ga]Ga-DOTATATE

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Journal of Nuclear Medicine Technology: 48 (4)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 4
December 1, 2020
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Poorly differentiated Neuroendocrine carcinoma (small cell) of Parotid Gland and ‘Moderately differentiated’ Hepatic metastases: a Discordant Histopathology clarified by dual tracer PET-CT (68Ga-DOTATATE and 18F-FDG) for predicting tumor biology and trea…
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Poorly differentiated Neuroendocrine carcinoma (small cell) of Parotid Gland and ‘Moderately differentiated’ Hepatic metastases: a Discordant Histopathology clarified by dual tracer PET-CT (68Ga-DOTATATE and 18F-FDG) for predicting tumor biology and treatment decision-making
Priyanka Sharma, Sandip Basu
Journal of Nuclear Medicine Technology Oct 2020, jnmt.120.251587; DOI: 10.2967/jnmt.120.251587

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Poorly differentiated Neuroendocrine carcinoma (small cell) of Parotid Gland and ‘Moderately differentiated’ Hepatic metastases: a Discordant Histopathology clarified by dual tracer PET-CT (68Ga-DOTATATE and 18F-FDG) for predicting tumor biology and treatment decision-making
Priyanka Sharma, Sandip Basu
Journal of Nuclear Medicine Technology Oct 2020, jnmt.120.251587; DOI: 10.2967/jnmt.120.251587
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Keywords

  • Neuroendocrine
  • Oncology: Endocrine
  • Oncology: Head and neck
  • PET/CT
  • FDG PET-CT
  • Neuroendocrine Tumour (NET)
  • Neuroendocrine neoplasm (NEN)
  • parotid gland
  • [68Ga]Ga-DOTATATE
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