RT Journal Article
SR Electronic
T1 Poorly differentiated Neuroendocrine carcinoma (small cell) of Parotid Gland and ‘Moderately differentiated’ Hepatic metastases: a Discordant Histopathology clarified by dual tracer PET-CT (68Ga-DOTATATE and 18F-FDG) for predicting tumor biology and treatment decision-making
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP jnmt.120.251587
DO 10.2967/jnmt.120.251587
A1 Priyanka Sharma
A1 Sandip Basu
YR 2020
UL http://tech.snmjournals.org/content/early/2020/10/02/jnmt.120.251587.abstract
AB Metastatic neuroendocrine neoplasms (NEN) of the parotid gland, with discordant histopathology reports between primary parotid tumor (poorly differentiated small cell neuroendocrine carcinoma) and large hepatic metastasis (atypical carcinoid with moderately differentiation status, Ki-67 15-20%), and the value of dual tracer PET-CT imaging (68Ga-DOTATATE and 18F-FDG) features in such clinical setting are illustrated. Minimal 68Ga-DOTATATE and high grade 18FDG uptake of the lesions indicated a poor differentiation status helped in clarifying tumor biology, with its potential implications for subsequent treatment-decision individualization in favor of chemotherapy. The findings underscore the clinical utility of dual tracer PET-CT in appropriating the assessment in patients/situations with conflicting or discordant histopathology at two sites in an individual.