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Journal of Nuclear Medicine Technology

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Radioassay

A New Economical Method for Determination of Triiodothyronine (T3) Uptake Using Talc Tablets

Wen-Chiao Wayne Lin and Leo V. dos Remedios
Journal of Nuclear Medicine Technology December 1978, 6 (4) 207-210;
Wen-Chiao Wayne Lin
Kaiser-Permanente Medical Center, Oakland, California
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Leo V. dos Remedios
Kaiser-Permanente Medical Center, Oakland, California
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Abstract

The determination of T3 uptake is necessary to find the free thyroxine index, increasingly used as the simplest accurate measure of thyroid dysfunction. A T3 uptake determination requires a reproducible, readily automated, and cost-effective method of adsorbent separation. Five adsorbent separating reagents were studied: hemoglobin-coated charcoal, dextrancoated charcoal, magnesium carbonate, anion-exchange resin, and talc tablets. Of these, binding efficiency was best with talc tablets. Talc binding was insensitive to incubation time, eliminating problems associated with other reagents. To maintain the conventional normal range for T3 uptake (25-35%), the quantities of talc, tracer, and serum used required adjustment. Results obtained with talc were compared to those obtained with a commercial kit, using paired sera from 897 patients. The correlation coefficient was 0.95 (P<0.0005). The coefficients of variation (CV) for 36 runs were 4.6%, 2.3%, and 2.1% inter-assay, and 3.3 %, 1.7%, and 1.04% intra-assay for hypothyroid, euthyroid, and hyperthyroid controls, respectively.

Footnotes

  • ↵* Present address: Clinical BioResearch, Div. of ABDEC, Inc., Emeryville, CA.

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Journal of Nuclear Medicine Technology: 6 (4)
Journal of Nuclear Medicine Technology
Vol. 6, Issue 4
December 1, 1978
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A New Economical Method for Determination of Triiodothyronine (T3) Uptake Using Talc Tablets
Wen-Chiao Wayne Lin, Leo V. dos Remedios
Journal of Nuclear Medicine Technology Dec 1978, 6 (4) 207-210;

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A New Economical Method for Determination of Triiodothyronine (T3) Uptake Using Talc Tablets
Wen-Chiao Wayne Lin, Leo V. dos Remedios
Journal of Nuclear Medicine Technology Dec 1978, 6 (4) 207-210;
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  • Evaluation of New T3 Uptake and Total T4 Tests
  • Comparison of Certain Aspects of 24 Thyroxine I-125 Kits
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