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Research ArticleImaging

Improved Correlation of 18F-Flortaucipir PET SUVRs and Clinical Stages in the Alzheimer Disease Continuum with the MUBADA/PERSI-Based Analysis

Yasuhiko Ikari, Go Akamatsu, Keiichi Matsumoto, Tomohiko Yamane, Michio Senda, Kazuki Fukuchi and AMED Preclinical AD Study Investigators, and Alzheimer’s Disease Neuroimaging Initiative Investigators
Journal of Nuclear Medicine Technology December 2024, 52 (4) 340-347; DOI: https://doi.org/10.2967/jnmt.123.267113
Yasuhiko Ikari
1Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Kobe, Japan;
2Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Japan;
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Go Akamatsu
1Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Kobe, Japan;
3National Institutes for Quantum Science and Technology, Chiba, Japan; and
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Keiichi Matsumoto
1Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Kobe, Japan;
4Department of Radiological Technology, Faculty of Medical Science, Kyoto College of Medical Science, Nantan, Japan
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Tomohiko Yamane
1Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Kobe, Japan;
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Michio Senda
1Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, Kobe, Japan;
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Kazuki Fukuchi
2Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Japan;
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Abstract

The Alzheimer disease (AD) continuum is a neurodegenerative disorder with cognitive decline and pathologic changes. Tau PET imaging can detect tau pathology, and 18F-flortaucipir PET imaging is expected to visualize progression through the stages of AD, for which quantitative assessment is essential. Two measurement methods, statistically defined multiblock barycentric discriminant analysis (MUBADA)/parametric estimation of reference signal intensity (PERSI) and anatomically defined tau meta–volume of interest (VOI)/cerebellar gray matter (CGM) for SUV ratio (SUVR), were compared in this study to assess their relationship to AD clinical stage using 2 open multicenter PET databases. Methods: Data were selected for 106 cases from 2 databases, AMED Preclinical AD study (AMED-PRE) (n = 15) and Alzheimer Disease Neuroimaging Initiative 3 (n = 91). The data of the participants were categorized into 4 groups based on the clinical criteria. Tau PET imaging was conducted using 18F-flortaucipir, and the 2 SUVR measurement methods, MUBADA/PERSI and tau meta-VOI/CGM, were compared among different clinical categories: amyloid-negative cognitively normal, preclinical AD, amyloid-negative mild cognitive impairment (MCI), and amyloid-positive MCI. Results: Significant differences were found between cognitively normal and preclinical AD, as well as between cognitively normal and amyloid-positive MCI and between amyloid-negative MCI and -positive MCI in SUVR derived by MUBADA/PERSI, whereas SUVR by tau meta-VOI/CGM did not provide significant differences between any pair. The tau meta-VOI/CGM method consistently provided higher SUVRs and larger individual variations than MUBADA/PERSI, with a mean SUVR difference of 0.136 for the studied databases. Conclusion: MUBADA/PERSI provided the SUVR of 18F-flortaucipir uptake with better association with the clinical severity of the AD continuum and with smaller variability. The results support the usefulness of MUBADA/PERSI as a quantitative measure of 18F-flortaucipir uptake in multicenter studies using different PET systems and scanning methods. However, limitations of the study include the small sample size and the unbalanced distribution among clinical categories in the AMED Preclinical AD study database.

  • tau PET
  • quantitative analysis
  • AD continuum
  • ADNI
  • MUBADA/PERSI

Footnotes

  • Published online Mar. 12, 2024.

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Journal of Nuclear Medicine Technology: 52 (4)
Journal of Nuclear Medicine Technology
Vol. 52, Issue 4
December 1, 2024
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Improved Correlation of 18F-Flortaucipir PET SUVRs and Clinical Stages in the Alzheimer Disease Continuum with the MUBADA/PERSI-Based Analysis
Yasuhiko Ikari, Go Akamatsu, Keiichi Matsumoto, Tomohiko Yamane, Michio Senda, Kazuki Fukuchi, AMED Preclinical AD Study Investigators, and Alzheimer’s Disease Neuroimaging Initiative Investigators
Journal of Nuclear Medicine Technology Dec 2024, 52 (4) 340-347; DOI: 10.2967/jnmt.123.267113
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Keywords

  • tau PET
  • quantitative analysis
  • AD continuum
  • ADNI
  • MUBADA/PERSI
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Improved Correlation of 18F-Flortaucipir PET SUVRs and Clinical Stages in the Alzheimer Disease Continuum with the MUBADA/PERSI-Based Analysis
Yasuhiko Ikari, Go Akamatsu, Keiichi Matsumoto, Tomohiko Yamane, Michio Senda, Kazuki Fukuchi, AMED Preclinical AD Study Investigators, and Alzheimer’s Disease Neuroimaging Initiative Investigators
Journal of Nuclear Medicine Technology Dec 2024, 52 (4) 340-347; DOI: 10.2967/jnmt.123.267113

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