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Journal of Nuclear Medicine Technology

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Research ArticlePractical Protocol Tip

Cardiac Amyloidosis Imaging

Mary Beth Farrell
Journal of Nuclear Medicine Technology June 2023, 51 (2) 99-101; DOI: https://doi.org/10.2967/jnmt.123.265538
Mary Beth Farrell
CNMT, NCT
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    TABLE 1.

    Radiopharmaceutical Identity, Dose, and Route of Administration

    IdentityDoseRoute of administration
    99mTc-pyrophosphate370–740 MBq (10–20 mCi)Intravenous
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    TABLE 2.

    99mTc-Pyrophosphate Cardiac Amyloidosis Imaging Parameters

    ParameterCharacteristicsStandard, optional, or preferred
    Camera typeLarge-field-of-view γ-cameraStandard
    Cadmium zinc tellurideOptional*
    Energy peak140 keVStandard
    Energy window15%–20%Standard
    CollimatorLow-energy, all-purposeStandard
    Patient positionSupineStandard
    Field of viewHeart/chestStandard
    Injection-to-imaging time3 hStandard
    1 hOptional
    Planar
     Acquisition typeStaticStandard
     Whole-body imagingOptional†
     Detector configuration90°Standard
     ViewsAnterior and left lateralStandard
     Number of views2Standard
     Counts per view750,000Standard
     Matrix256 × 256Standard
     Magnification1.46
    SPECT or SPECT/CT*
     Acquisition typeStep and shoot or continuousStandard
     Patient positionSupineStandard
     UprightOptional
     Orbit180°/90°Standard
     360°/180°Optional
     Matrix128 × 128 (minimum, 64 × 64)Standard
     Magnification1.46 (180° orbit)Standard
     1.0 (360° orbit)Optional
     Pixel size2.3–6.5 mmStandard
     Projections/detector40/32Standard
     Time/projection20 s/25 sStandard
     CT attenuation correctionHeartPreferred
    • ↵* Parameters defined for γ-cameras as parameters for cadmium-zinc-telluride cameras have not been firmly established.

    • ↵† Whole-body imaging is not performed when imaging with 99mTc-pyrophosphate. However, whole-body imaging is useful when imaging with 99mTc-HMDP or 99mTc-DPD to demonstrate soft-tissue uptake.

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    TABLE 3.

    SPECT Semiquantitative Visual Scoring

    GradeDescription
    0No myocardial uptake and normal bone uptake
    1Myocardial uptake less than rib uptake
    2Myocardial uptake equal to rib uptake
    3Myocardial uptake greater than rib uptake with mild or absent uptake
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Journal of Nuclear Medicine Technology: 51 (2)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 2
June 1, 2023
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Cardiac Amyloidosis Imaging
Mary Beth Farrell
Journal of Nuclear Medicine Technology Jun 2023, 51 (2) 99-101; DOI: 10.2967/jnmt.123.265538

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Cardiac Amyloidosis Imaging
Mary Beth Farrell
Journal of Nuclear Medicine Technology Jun 2023, 51 (2) 99-101; DOI: 10.2967/jnmt.123.265538
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