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Journal of Nuclear Medicine Technology

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Research ArticleInvited Perspective

The Rise of Cardiac Amyloidosis Imaging

Bharadwaj Satyavolu, Joseph Deitz and Prem Soman
Journal of Nuclear Medicine Technology June 2023, 51 (2) 129-132; DOI: https://doi.org/10.2967/jnmt.123.265635
Bharadwaj Satyavolu
Division of Cardiology and Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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Joseph Deitz
Division of Cardiology and Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
CNMT
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Prem Soman
Division of Cardiology and Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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  • FIGURE 1.
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    FIGURE 1.

    (A) Positive [99mTc]Tc-pyrophosphate scan showing Perugini grade 3 uptake with heart–to–contralateral-lung ratio of 2.13 on planar imaging. (B) Diffuse tracer uptake on SPECT images. Contemporary diagnostic standard for [99mTc]Tc-pyrophosphate is SPECT imaging. Planar imaging performed alone leads to high percentage of false-positive studies.

  • FIGURE 2.
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    FIGURE 2.

    Two-dimensional echocardiography: (A) Parasternal long axis view with left ventricular hypertrophy (white arrows). (B and C) Apical sparing longitudinal strain abnormality.

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    FIGURE 3.

    Four-chamber view of cardiac MRI showing diffuse subendocardial late gadolinium enhancement. Arrows point to late gadolinium enhancement on left ventricular and right ventricular sides of interventricular septum, resulting in train-track appearance.

Tables

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    TABLE 1.

    CA Red Flags

    CategoryRed flag
    ClinicalHeart failure and intolerance to β-blockers and angiotensin-converting enzyme inhibitors
    Heart failure and peripheral or autonomic neuropathy
    Left ventricular hypertrophy with persistently elevated troponin levels
    History of bilateral carpal tunnel release
    Periorbital purpura
    Heart failure with nephrotic syndrome
    Macroglossia
    Spontaneous tendon rupture, especially biceps tendon rupture (Popeye sign)
    Lumbar spinal stenosis
    Plasma cell dyscrasia: elevated free light chains or abnormal serum or urine immunofixation
    EchocardiographicUnexplained left ventricular hypertrophy with…
     Biatrial enlargement
     Pericardial effusion
     Reduced global longitudinal strain, characteristically apical-sparing pattern
     Low-flow, low-gradient aortic stenosis
    ElectrocardiographicLow-voltage QRS complex in setting of left ventricular hypertrophy
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In this issue

Journal of Nuclear Medicine Technology: 51 (2)
Journal of Nuclear Medicine Technology
Vol. 51, Issue 2
June 1, 2023
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The Rise of Cardiac Amyloidosis Imaging
Bharadwaj Satyavolu, Joseph Deitz, Prem Soman
Journal of Nuclear Medicine Technology Jun 2023, 51 (2) 129-132; DOI: 10.2967/jnmt.123.265635

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The Rise of Cardiac Amyloidosis Imaging
Bharadwaj Satyavolu, Joseph Deitz, Prem Soman
Journal of Nuclear Medicine Technology Jun 2023, 51 (2) 129-132; DOI: 10.2967/jnmt.123.265635
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Jump to section

  • Article
    • RISE IN DIAGNOSTIC IMAGING
    • BONE-SEEKING TRACERS USEFUL FOR DIAGNOSIS OF TRANSTHYRETIN CA
    • EVOLUTION OF CARDIAC SCINTIGRAPHY WITH BONE-SEEKING TRACERS FOR TRANSTHYRETIN CA
    • OTHER IMAGING MODALITIES FOR TRANSTHYRETIN CA
    • POTENTIAL PITFALLS IN THE DIAGNOSIS OF TRANSTHYRETIN CA
    • SUMMARY
    • DISCLOSURE
    • REFERENCES
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