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Journal of Nuclear Medicine Technology

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Research ArticleContinuing Education: MRI and PET/MRI

PET/MRI, Part 4: Clinical Applications

Geoffrey M. Currie, Jose Leon, Elad Nevo and Peter Kamvosoulis
Journal of Nuclear Medicine Technology June 2022, 50 (2) 90-96; DOI: https://doi.org/10.2967/jnmt.121.263288
Geoffrey M. Currie
1School of Dentistry and Health Science, Charles Sturt University, Wagga Wagga, Australia;
2Department of Radiology, Baylor College of Medicine, Houston, Texas;
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Jose Leon
3Core for Translational Research in Imaging, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland;
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Elad Nevo
4Department of Radiology, Lucille Packard Children’s Hospital, Stanford University, Palo Alto, California;
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Peter Kamvosoulis
5Magnetic Resonance Department, New York–Presbyterian/Weill Cornell Medical Center, New York, New York; and
6Imaging Research, Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York
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    FIGURE 1.

    Yearly publication numbers from PubMed for PET/MRI (orange) compared with PET/CT (blue). Dashed lines are corresponding moving averages. PET/MRI showed almost exponential growth until 2015 before flattening of curve. Adjustment of 2021 data is based on projection from data collection point 80% through year.

  • FIGURE 2.
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    FIGURE 2.

    Yearly publication numbers for 2020 from PubMed for PET/MRI show that cancer has greatest engagement, followed by brain, other (unlisted applications), cardiac, and pediatric.

  • FIGURE 3.
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    FIGURE 3.

    Yearly publication numbers for 2020 from PubMed for PET/MRI for various oncology applications suggest that prostate, brain, and neuroendocrine (including pancreatic) are most significant applications.

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    FIGURE 4.

    Patient with left ventricular ejection fraction of 30% and inferior-to-posterolateral akinesia on echocardiography. 18F-FDG PET/MRI shows decreased metabolic activity of posterolateral wall (A and D), corresponding to late gadolinium enhancement on MR images (C and F) and confirmed on fused images (B and E). (Reprinted from (31).)

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    FIGURE 5.

    Poorly differentiated squamous cell carcinoma of cervix on CT (A, left) and PET/CT (A, right), with corresponding unenhanced T2-weighted turbo spin-echo CT (B, left) and T2-weighted turbo spin-echo PET/MRI (B, right) and contrast-enhanced sagittal MRI T1-weighted MRI (Dixon–visual background extractor sequence) (C, left) and PET/MRI (C, right). (Reprinted from (32).)

  • FIGURE 6.
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    FIGURE 6.

    Simultaneous PET/MRI in dementia using 18F-florbetaben PET and pulsed arterial spin labeling (pASL) MRI. MPRAGE = magnetization-prepared rapid gradient echo. (Reprinted from (33).)

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Journal of Nuclear Medicine Technology: 50 (2)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 2
June 1, 2022
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PET/MRI, Part 4: Clinical Applications
Geoffrey M. Currie, Jose Leon, Elad Nevo, Peter Kamvosoulis
Journal of Nuclear Medicine Technology Jun 2022, 50 (2) 90-96; DOI: 10.2967/jnmt.121.263288

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PET/MRI, Part 4: Clinical Applications
Geoffrey M. Currie, Jose Leon, Elad Nevo, Peter Kamvosoulis
Journal of Nuclear Medicine Technology Jun 2022, 50 (2) 90-96; DOI: 10.2967/jnmt.121.263288
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  • Article
    • Abstract
    • CARDIOLOGY APPLICATIONS OF PET/MRI
    • ONCOLOGY APPLICATIONS OF PET/MRI
    • NEUROLOGIC APPLICATIONS OF PET/MRI
    • PEDIATRIC APPLICATIONS OF PET/MRI
    • CONCLUSION
    • DISCLOSURE
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  • PET/MRI
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