Article Figures & Data
Figures
- FIGURE 1.
Increased uptake in left-sided paravertebral mass and invading the spinal canal and adjacent vertebral body of T3 (blue arrows).
- FIGURE 2.
Uptake in left suprarenal mass, with areas of necrosis (blue arrows) and evidence of skeletal metastasis (white arrows) and bone marrow infiltration.
- FIGURE 3.
Heterogeneous uptake in lobulated right suprarenal mass (blue arrows), with diffuse skeletal metastasis, including in skull and pelvis (white arrows), and diffuse bone marrow infiltration.
- FIGURE 4.
Summary of PET images for patients 1–3.
Tables
Characteristic Patient 1 Patient 2 Patient 3 Age 23 mo 6 y 3.5 y Sex Male Female Female Clinical presentation Ataxia, irritability, progressing to paraparesis Limp, discomfort on left side of abdomen Body pain, swelling of left eye, weight loss, cachexia Histopathology Poorly differentiated neuroblastoma Poorly differentiated neuroblastoma Not done Cytogenetics Not done N-Myc Not amplified Not amplified SCA (1p−, 11q+, any other, LOH) Not seen 1q+, 11q−, 17q+, X−, no LOH Alk No rearrangement No rearrangement NCA Not seen Not seen Bone marrow No evidence of infiltration Infiltrated by nonhematopoietic tumor, neuroblastoma Infiltrated by nonhematopoietic tumor, neuroblastoma Urinary catecholamines VMA/creatinine ratio 14.1 (0–6.3) 90.7 (0–4.7) 209.8 (0–6.3) HVA/creatinine ratio 9.9 (0–13.6) 95.6 (0–9.4) 191.0 (0–13.6) SCA = segmental chromosomal abnormalities; LOH = loss of heterozygosity; NCA = numerical chromosomal abnormalities; 1p− = 1 p deletion; 11q− = 11q deletion; 17q+ = gain of 17q; X− = deletion of X-chromosome; N-Myc = N-Myc oncogene; Alk = anaplastic lymphoma kinase; VMA = vanillylmandelic acid; HVA = homovanillic acid.
Data in parentheses represent reference range.
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