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Research ArticleImaging

Correlation of Lesional Uptake Parameters and Ratios with miPSMA Score and Estimating Normal Physiologic Concentration: An Exploratory Analysis in Metastatic Castration-Resistant Prostatic Carcinoma Patients with 68Ga-PSMA-11 PET/CT

Ashwini Kalshetty, Biju Menon, Sutapa Rakshit, Atanu Bhattacharjee and Sandip Basu
Journal of Nuclear Medicine Technology September 2021, 49 (3) 235-240; DOI: https://doi.org/10.2967/jnmt.120.261289
Ashwini Kalshetty
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Mumbai, India;
2Homi Bhabha National Institute, Mumbai, India; and
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Biju Menon
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Mumbai, India;
2Homi Bhabha National Institute, Mumbai, India; and
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Sutapa Rakshit
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Mumbai, India;
2Homi Bhabha National Institute, Mumbai, India; and
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Atanu Bhattacharjee
2Homi Bhabha National Institute, Mumbai, India; and
3Department of Biostatistics, ACTREC, Tata Memorial Centre, Mumbai, India
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Sandip Basu
1Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Mumbai, India;
2Homi Bhabha National Institute, Mumbai, India; and
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  • FIGURE 1.
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    FIGURE 1.

    Schema for drawing volumes of interest adopted in this study.

  • FIGURE 2.
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    FIGURE 2.

    Average SUVmax and SUVmean for different organs.

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    FIGURE 3.

    SUVmax, T/L ratio, T/S ratio, and T/P ratio for lesion 2 and lesion 3. Color version of this figure is available as supplemental file at http://tech.snmjournals.org.

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    FIGURE 4.

    Comparison of SUVmax, T/L ratio, T/S ratio, and T/P ratio between scores 2 and 3.

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    TABLE 1

    Patient Characteristics and Previous Therapies

    ParameterData
    Age (y)
     Mean ± SD67.5 ± 8
     Range52–84
    Serum prostate-specific antigen (ng/mL)
     Mean ± SD401 ± 1,353
     Range0.098–9,235.13
    Gleason score
     Group 11
     Group 26
     Group 39
     Group 417
     Group 517
    Surgery (prostatectomy ± orchidectomy) (n)
     Yes50 (100%)
     No0 (0%)
    Hormonal treatment (n)
     Yes46 (92%)
     No4 (8%)
    Chemotherapy (n)
     Yes39 (78%)
     No11 (22%)
    External-beam radiation therapy (n)
     Yes24 (48%)
     No26 (52%)
    177Lu-PSMA therapy (n)
     Yes16 (32%)
     No34 (68%)
    Initial staging (n)
     Yes11 (22%)
     No39 (78%)
    Restaging (n)
     Yes45 (90%)
     No5 (10%)
    • View popup
    TABLE 2

    SUVmean and SUVmax for Normal Organs

    OrganSUVmeanSUVmax
    Liver3.98 ± 1.745.89 ± 2.32
    Spleen6.71 ± 3.89.33 ± 4.98
    Kidneys24.13 ± 1537.72 ± 22.1
    Submandibular glands9.16 ± 4.5615.44 ± 7.34
    Parotid glands9.51 ± 5.0814.36 ± 7.05
    Lacrimal glands2.64 ± 1.466.16 ± 3.68
    Blood pool1.52 ± 1.222.36 ± 1.95
    Bowel7.7 ± 4.3413.81 ± 7.6
    Tubarial glands2.7 ± 1.975.3 ± 1.41
    • Data are mean ± SD.

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    TABLE 3

    Comparative Uptake Values and Ratios of Lesions

    ParameterScore of 2Score of 3P
    Sample size (n)1139
    Average SUVmax10.33 ± 3.2738.2 ± 25.920.0009
    SUVmax range6.46–17.007.6–119.08
    Average T/S1.21 ± 0.445.05z ± 4.460.0068
    T/S range0.48–2.041.25–20.89
    Average T/L1.67 ± 0.466.98 ± 3.850.00004
    T/L range1.2–2.41.4–16.56
    Average T/P0.61 ± 0.183.15 ± 2.090.00021
    T/P range0.39–0.871.06–9.45
    • Data are mean ± SD or range.

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    TABLE 4

    Comparative Temporal Variation of Mean SUV of Normal Organs with Their P Values

    OrganSUVmeanSUVmaxSUVmean delayedSUVmax delayedSUVmeanPSUVmaxP
    Liver3.65.93.16.70.02220.14
    Spleen6.59.45.89.10.00010.594
    Kidneys20.135.721.541.70.0950.016
    Submandibular glands7.413.48.116.60.5410.002
    Parotid glands7.112.98.514.10.0470.037
    Lacrimal glands4.28.14.58.30.02670.01
    Aorta1.332.22.12.10.4110.914
    Bowel5.59.75.410.90.410.44
    Tubarial glands2.875.553.36.060.020.08
    • View popup
    TABLE 5

    Paired t Test Mean Values for Temporal Variation of Lesional Parameters Between Early and Delayed Images

    ParameterEarly imagingDelayed imagingPaired t test P
    SUVmax18.8526.240.0001
    T/L ratio5.96.650.45
    T/S ratio12.8914.120.84
    T/P ratio9.369.050.62

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Journal of Nuclear Medicine Technology: 49 (3)
Journal of Nuclear Medicine Technology
Vol. 49, Issue 3
September 1, 2021
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Correlation of Lesional Uptake Parameters and Ratios with miPSMA Score and Estimating Normal Physiologic Concentration: An Exploratory Analysis in Metastatic Castration-Resistant Prostatic Carcinoma Patients with 68Ga-PSMA-11 PET/CT
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Correlation of Lesional Uptake Parameters and Ratios with miPSMA Score and Estimating Normal Physiologic Concentration: An Exploratory Analysis in Metastatic Castration-Resistant Prostatic Carcinoma Patients with 68Ga-PSMA-11 PET/CT
Ashwini Kalshetty, Biju Menon, Sutapa Rakshit, Atanu Bhattacharjee, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2021, 49 (3) 235-240; DOI: 10.2967/jnmt.120.261289

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Correlation of Lesional Uptake Parameters and Ratios with miPSMA Score and Estimating Normal Physiologic Concentration: An Exploratory Analysis in Metastatic Castration-Resistant Prostatic Carcinoma Patients with 68Ga-PSMA-11 PET/CT
Ashwini Kalshetty, Biju Menon, Sutapa Rakshit, Atanu Bhattacharjee, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2021, 49 (3) 235-240; DOI: 10.2967/jnmt.120.261289
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Keywords

  • 68Ga-PSMA-11 PET/CT
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  • metastatic castration-resistant prostate carcinoma
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